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CC BY-NC-ND 4.0 · South Asian J Cancer 2014; 03(03): 147-150
DOI: 10.4103/2278-330X.136764
MINI SYMPOSIUM: HEAD AND NECK CANCER : Review Article

Organ preservation strategies: Review of literature and their applicability in developing nations

Authors

  • Mitali Dandekar

    Department of Head Neck Surgery, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India

  • Anil D'Cruz

    Department of Head Neck Surgery, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India

Source of Support: Nill.
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Abstract

There has been a change in practice in locally advanced laryngopharyngeal cancers toward non-surgical treatment modalities. Although, there have been landmark trials pertinent to organ preservation, their applicability in developing nations is a topic of much debate. The organ preservation concept was based on the findings of pivotal trials by the Veterans Affairs, European Organization for Research and Treatment of Cancer group and Radiation Therapy Oncology Group. Subsequently numerous studies have been designed to evaluate intensification of treatment as well as study toxicity and tolerability. This review critically analyses current evidence for larynx preservation, experience from various centers on organ preservation strategies as well as applicability of these protocols to developing nations.

Key words

Chemoradiotherapy - clinical protocols - developing countries


Publication History

Article published online:
31 December 2020

© 2014. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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