Download PDF
CC BY-NC-ND 4.0 · European Journal of General Dentistry 2013; 2(03): 328-331
DOI: 10.4103/2278-9626.116007
Short Communication

Adenomatoid odontogenic tumor expressing p53 and PCNA: A true benign neoplasm?

Kunal Sah
Department of Oral Pathology and Microbiology, Saraswati Dental College and Hospital, Faizabad Road, Lucknow, Uttar Pradesh, India
,
Alka D. Kale
1   Department of Oral Pathology and Microbiology, VK KLE Institute of Dental Sciences, KLE University, Belgaum, Karnataka, India
,
Vijaylaxmi Kotrashetti
1   Department of Oral Pathology and Microbiology, VK KLE Institute of Dental Sciences, KLE University, Belgaum, Karnataka, India
,
Sunira Chandra
2   Department of Oral Medicine and Radiology, Saraswati Dental College and Hospital, Faizabad Road, Lucknow, Uttar Pradesh, India
› Author Affiliations
› Further Information
Also available at
 PDF Download Permissions and Reprints

Abstract

Adenomatoid odontogenic tumor (AOT) is a relatively uncommon distinct odontogenic neoplasm. Histogenesis of AOT is still uncertain, and whether it represents anomalous hamartomatous growth or a true benign neoplasm is debatable. We report herein an unusual case of AOT occurring in the mandible. The tumor showed an unusual and aggressive clinical course, location, and radiographical and histopathological features expressing PCNA and p53 protein, which are suggestive of its proliferative potential, aggressive tumor behavior, and invasive characteristics. Based on these evidences, we suggested it to be a benign aggressive neoplasm rather than a hamartoma, though based on the analysis of single case it is still debatable.

Keywords

Adenomatoid odontogenic tumor - mandible - neoplasm - p53 protein - PCNA


Publication History

Article published online:
01 November 2021

© 2013. European Journal of General Dentistry. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Garg D, Palaskar S, Shetty VP, Bhushan A. Adenomatoid odontogenic tumor-hamartoma or true neoplasm: A case report. J Oral Sci 2009;51:155-9.
  • 2 Philipsen HP, Reichart PA, Siar CH, Ng KH, Lau SH, Zhang X, et al. An updated clinical and epidemiological profile of the adenomatoid odontogenic tumour: A collaborative retrospective study collaborative retrospective study. J Oral Pathol Med 2007;36:383-93.
  • 3 Yilmaz N, Acikgoz A, Celebi N, Zengin AZ, Gunhan O. Extrafollicular adenomatoid odontogenic tumor of the mandible: Report of a case. Eur J Dent 2009;3:71-4.
  • 4 Nomura M, Tanimoto K, Takata T, Shimosato T. Mandibular adenomatoid odontogenic tumor with unusual clinicopathologic features. J Oral Maxillofac Surg 1992;50:282-5.
  • 5 Handschel JG, Depprich RA, Zimmermann AC, Braunstein S, Kübler NR. Adenomatoid odontogenic tumor of the mandible: Review of the literature and report of a rare case. Head Face Med 2005;1:3.
  • 6 Gnepp DR, Chen JC, Warren C. Polymorphous low grade adenocarcinoma of minor salivary gland. An immunohistochemical and clinicopathologic study. Am J Surg Pathol 1988;12:461-8.
  • 7 Dhanuthai K, Chantarangsu S, Swasdison S. Proliferating cell nuclear antigen expression in odontogenic cysts and ameloblastomas. Asian J Oral Maxillofac Surg 2005;17:6-10.
  • 8 Suzuki H, Hashimoto K. Adenomatoid odontogenic tumour of the maxilla: Immunohistochemical study. Asian J Oral Maxillofac Surg 2005;17:267-2.
  • 9 Crivelini MM, Soubhia AM, Renata Callestini Felipini RC. Study on the origin and nature of the AOT by immunohistochemistry J Appl Oral Sci 2005;13:406-12.
  • 10 de Medeiros AM, Nonaka CF, Galvão HC, Souza LB, Freitas Rde A. Expression of extracellular matrix proteins in ameloblastoma and adenomatoid odontogenic tumors. Eur Arch Otorhinolaryngol 2010;267:303-10.
  • 11 Leon JE, Mata GM, Fregnani ER, Carlos-Bregni R, de Almeida OP, Mosqueda-Taylor A, et al. Clinicopathological and immunohistochemical study of 39 cases of adenomatoid odontogenic tumour: A multicentric study. Oral Oncol 2005;41:835-42.
  • 12 Gomes CC, Oliveira Cda S, Castro WH, de Lacerda JC, Gomez RS. Clonal nature of odontogenic tumor. J Oral Pathol Med 2009;38:397-400.
  • 13 Nigam S, Gupta SK, Chaturvedi KU. Adenamatoid odontogenic tumor-a rare cause of jaw swelling. Braz Dent J 2005;16:251-3.
  • 14 Barboza CA, Pereira Pinto L, Freitas Rde A, Costa Ade L, Souza LB. Proliferating cell nuclear antigen and p53 protein expression in ameloblastoma and AOT. Braz Dent J 2005;16:56-61.