Download PDF
CC BY-NC-ND 4.0 · Avicenna J Med 2019; 09(04): 160-163
DOI: 10.4103/AJM.AJM_47_19
CASE REPORT

Nonmetastatic renal cell carcinoma presenting with persistent cough: Case report with literature review

Mohd Amer Alsamman
Hospital Medicine/Department of Internal Medicine, The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA; Internal Medicine, TriHealth Cancer Institute, Good Samaritan Hospital, TriHealth, Cincinnati, Ohio, USA
,
David Draper
Department of Hematology Oncology, TriHealth Cancer Institute, Good Samaritan Hospital, TriHealth, Cincinnati, Ohio, USA
› Author Affiliations Financial support and sponsorship Nil.
› Further Information
   Permissions and Reprints

Abstract

Renal cell carcinomas (RCC), constitute 80– 85% of primary renal neoplasms. The classic triad of RCC (flank pain, hematuria, and a palpable abdominal renal mass) occurs in approximately 9% of patients; it strongly suggests locally advanced disease. RCC may also be associated with a number of paraneoplastic syndromes. These are typically due to ectopic production of various hormones. We present a 69-year-old male patient previously healthy presented to the emergency department with recurrent persistent cough. A non-metastatic RCC was incidentally discovered. Eventually, he underwent left radical nephrectomy. One year has passed with no cough. This is a rare and unusual presentation of RCC that falls under the category of paraneoplastic syndrome with review of similar reported cases and summary of all paraneoplastic syndromes associated with RCC in literature.

Keywords

Cough - paraneoplastic syndrome - prostaglandins - renal cell carcinoma


Publication History

Article published online:
09 August 2021

© 2019. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

  • References

  • 1 Skinner DG, Colvin RB, Vermillion CD, Pfister RC, Leadbetter WF. Diagnosis and management of renal cell carcinoma .A clinical and pathologic study of 309 cases. Cancer 1971; 28: 1165-77
    CrossrefPubMedGoogle Scholar
  • 2 Gold PJ, Fefer A, Thompson JA. Paraneoplastic manifestations of renal cell carcinoma. Semin Urol Oncol 1996; 14: 216-22
    PubMedGoogle Scholar
  • 3 Maher SA, Birrell MA, Belvisi MG. Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy. Am J Respir Crit Care Med 2009; 180: 923-8
    CrossrefPubMedGoogle Scholar
  • 4 Chung KF, Pavord ID. Prevalence, pathogenesis, and causes of chronic cough. Lancet 2008; 371: 1364-74
    CrossrefPubMedGoogle Scholar
  • 5 Mukae S, Itoh S, Aoki S, Iwata T, Nishio K, Sato R. et al. Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough. J Hum Hypertens 2002; 16: 857-63
    CrossrefPubMedGoogle Scholar
  • 6 Okubo Y, Yonese J, Kawakami S, Yamamoto S, Komai Y, Takeshita H. et al. Obstinate cough as a sole presenting symptom of non-metastatic renal cell carcinoma. Int J Urol 2007; 14: 854-5
    CrossrefPubMedGoogle Scholar
  • 7 Estfan B, Walsh D. The cough from hell: diazepam for intractable cough in a patient with renal cell carcinoma. J Pain Symptom Manage 2008; 36: 553-8
    CrossrefPubMedGoogle Scholar
  • 8 Fujikawa A, Daidoh Y, Taoka Y, Nakamura S. Immediate improvement of a persistent cough after tumor embolization for renal cell carcinoma–a rare manifestation of paraneoplastic syndrome. Scand J Urol Nephrol 2002; 36: 393-5
    CrossrefPubMedGoogle Scholar
  • 9 Roberts L, Wood G, Whitby M, Heathcote P. An unusual case of chronic cough. Aust N Z J Med 1991; 21: 780
    CrossrefPubMedGoogle Scholar
  • 10 Sandhu DP, Munson KW, Harrop JS, Hopton MR, Ratcliffe WA. Humoral hypercalcaemia in renal carcinoma due to parathyroid hormone related protein. Br J Urol 1993; 72: 848-50
    CrossrefPubMedGoogle Scholar
  • 11 Palapattu GS, Kristo B, Rajfer J. Paraneoplastic syndromes in urologic malignancy: the many faces of renal cell carcinoma. Rev Urol 2002; 4: 163-70
    PubMedGoogle Scholar
  • 12 Walsh PN, Kissane JM. Nonmetastatic hypernephroma with reversible hepatic dysfunction. Arch Intern Med 1968; 122: 214-22
    CrossrefPubMedGoogle Scholar
  • 13 Pras M, Franklin EC, Shibolet S, Frangione B. Amyloidosis associated with renal cell carcinoma of the AA type. Am J Med 1982; 73: 426-8
    CrossrefPubMedGoogle Scholar
  • 14 Sinha S, O’keefe SC, Marshall FF, Issa MM, Petros JA. Thrombocytosis is Associated with a significant increase in the cancer specific death rate after radical nephrectomy. J Urol 2002; 168: 1378-80
    CrossrefPubMedGoogle Scholar
  • 15 Sidhom OA, Basalaev M, Sigal LH. Renal cell carcinoma presenting as polymyalgia rheumatica. Resolution after nephrectomy. Arch Intern Med 1993; 153: 2043-5
    CrossrefPubMedGoogle Scholar
  • 16 Turk HM, Ozet A, Kuzhan O, Komurcu F, Arpaci F, Ozturk B. et al. Paraneoplastic motor neuron disease resembling amyotrophic lateral sclerosis in a patient with renal cell carcinoma. Med Princ Pract 2009; 18: 73-5
    CrossrefPubMedGoogle Scholar