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DOI: 10.4103/ajm.AJM_81_17
Submandibular lipoblastoma: Case report of a rare tumor in childhood
Financial support and sponsorship Nil.Abstract
Lipoblastoma is a rare, benign tumor usually occurring in childhood. It is essentially localized in the extremities and trunk, with few cases reported in the neck. We report the case of a 2-year-old girl with a rapidly enlarging, painless neck mass. Magnetic resonance imaging (MRI) revealed a 3-cm mass in the right submandibular region. Review of literature, diagnostic methods, and genetics of lipomatous tumors are discussed. Complete surgical excision via a lateral cervical approach demonstrated a white soft tissue with an adherent ganglion. Histology and immunohistochemistry confirmed the diagnosis of lipoblastoma. Cervical lipoblastoma is rare, and typically asymptomatic, rarely causing nerve compression or airway obstruction. MRI can help identifying the lipomatous nature of the mass, but the findings can be inconsistent due to variable maturity of fat cells and the mesenchymal content of the tumor. Diagnosis is always based on pathological examination. Further chromosomal analysis is useful in differentiating lipoblastoma from liposarcoma. Complete surgical excision is the recommended treatment.
Publication History
Article published online:
12 August 2021
© 2018. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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References
- 1 Chung EB, Enzinger FM. Benign lipoblastomatosis. An analysis of 35 cases. Cancer 1973; 32: 482-92
- 2 Basaran UN, Inan M, Bilgi S, Pul M. Lipoblastoma: A rare cervical mass in childhood. Int J Pediatr Otorhinolaryngol 2001; 61: 265-8
- 3 Rasmussen IS, Kirkegaard J, Kaasbøl M. Intermittent airway obstruction in a child caused by a cervical lipoblastoma. Acta Anaesthesiol Scand 1997; 41: 945-6
- 4 O'Donnell KA, Caty MG, Allen JE, Fisher JE. Lipoblastoma: Better termed infantile lipoma?. Pediatr Surg Int 2000; 16: 458-61
- 5 Farrugia MK, Fearne C. Benign lipoblastoma arising in the neck. Pediatr Surg Int 1998; 13: 213-4
- 6 Dilley AV, Patel DL, Hicks MJ, Brandt ML. Lipoblastoma: Pathophysiology and surgical management. J Pediatr Surg 2001; 36: 229-31
- 7 Bruyeer E, Lemmerling M, Poorten VV, Sciot R, Hermans R. Paediatric lipoblastoma in the head and neck: Three cases and review of literature. Cancer Imaging 2012; 12: 484-7
-
8 Fletcher C, editor. Diagnostic Histopathology of Tumors. Vol. 2. New York: Churchill Livingstone; 1995. p. 1045.
- 9 Hicks J, Dilley A, Patel D, Barrish J, Zhu SH, Brandt M. et al. Lipoblastoma and lipoblastomatosis in infancy and childhood: Histopathologic, ultrastructural, and cytogenetic features. Ultrastruct Pathol 2001; 25: 321-33
- 10 Miller GG, Yanchar NL, Magee JF, Blair GK. Lipoblastoma and liposarcoma in children: An analysis of 9 cases and a review of the literature. Can J Surg 1998; 41: 455-8