CC BY-NC-ND 4.0 · Avicenna J Med 2020; 10(04): 198-207
DOI: 10.4103/ajm.ajm_17_20
Original Article

Aspirin dosage for the prevention of graft occlusion in people undergoing coronary surgery: a systematic review and meta-analysis

Fares Alahdab
Evidence-based Practice Center, Mayo Clinic, Rochester, Michigan,USA
Ruba Zuhri Yafi
Faculty of Medicine, Damascus University, Damascus, Syrian Arab Republic
Abdelkader Chaar
Department of Medicine, Yale New Haven Hospital, New Haven, Connecticut, USA
Ali Alrstom
Department of Medicine, Damascus University, Almwasat Hospital, Damascus, Syrian Arab Republic
Muayad Alzuabi
Department of Neurology, Medical University of South Carolina, Charleston, South Carolina
Omar Alhalabi
Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Somar Hasan
Department of Ophthalmology, Jena University Hospital, Jena, Germany
Mahmoud Mallak
Children’s University Hospital
Mohamad Luay Jazayerli
Faculty of Medicine, University of Damascus, Damascus, Syrian Arab Republic
Qusay Haydour
Department of Internal Medicine, Cleveland Clinic Akron General, Akron
Mohamad Alkhouli
Department of Cardiovascular Medicine, Mayo Clinic
Wedad Alfarkh
Department of Pathology, Baylor College of Medicine
Mohammad Hassan Murad
Mayo Evidence-based Practice Center (EPC), Mayo Clinic, Rochester, Michigan, USA
› Author Affiliations

Subject Editor: Financial support and sponsorship Nil.


Background: Aspirin is almost always used after coronary artery bypass graft (CABG) surgery; however, it is unclear what optimal dose should be prescribed. In this systematic review, we evaluated the effects of high versus low-dose aspirin in patients after CABG. Methods: A comprehensive database search was conducted in several databases from date of inception until February 2018. There were no language restrictions. We included studies that compared different doses of aspirin in patients that had undergone CABG surgery. We included studies that evaluated patient-important outcomes (mortality, cardiovascular events, and gastrointestinal bleeding); and if not reported, we collected data on the surrogate outcome thromboxane B2 (TXB2). We collected relevant data and performed a meta-analysis. Results: We identified 5903 references, and after two levels of screening by two independent reviewers, we included three randomized controlled trials in the meta-analysis with a total number of 122 participants. Mean age of trial participants was 65.63 years, and 88.68% were male. We planned to analyze all possible clinical outcomes, including mortality, recurrence, and hospitalization. However, no clinical outcomes are reported by the literature. The surrogate biochemical outcome of serum TXB2 was the only outcome reported by the eligible studies. High-dose aspirin (162–325 mg once daily) achieved better suppression of TXB2 than low-dose aspirin (75–100 mg once daily) (mean difference [MD], 2.00ng/mL, 95% confidence interval [CI]: 0.72–3.32; participants = 122; studies = 3; I2 = 0%). Conclusions: We found no clinical trials addressing any of the clinical outcomes of interest. High-dose aspirin was superior to low-dose aspirin in suppressing platelet function, a surrogate outcome. Trials evaluating clinical and patient-important outcomes are needed to better inform medical practice and fill this gap in clinical knowledge.

Publication History

Article published online:
04 August 2021

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