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CC BY-NC-ND 4.0 · Avicenna J Med 2021; 11(01): 49-53
DOI: 10.4103/ajm.ajm_183_20
Case Report

Sebaceous Carcinoma of the Vulva: A Case Report and Review of the Literature

Hind Alharthi
Princess Nora Bint Abdul Rahman University, College of Medicine
,
Hala Alnuaim
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
,
Ohoud Aljarbou
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
,
Haitham Arabi
Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
› Author Affiliations
Subject Editor: Financial support and sponsorship Nil.
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Abstract

Sebaceous carcinoma is a rare malignant cutaneous neoplasm that is most commonly arises in the ocular region. Although it can occur in extraocular sites, sebaceous carcinoma is rarely encountered in the vulva. The use of immunohistochemical staining is very crucial to exclude other differential diagnoses including primary cutaneous and metastatic neoplasms. Unlike ocular sebaceous carcinoma, little is known about the clinical behavior and the prognostic factors in vulvar sebaceous carcinoma. Herein, we present a case of vulvar sebaceous carcinoma in a 27-year-old female, who presented with a labial tumor with lung metastases. To the best of our knowledge, only 11 similar cases were previously reported in the literature.

Keywords

Vulva - vulvar carcinoma - vulvar sebaceous carcinoma


Publication History

Article published online:
06 August 2021

© 2021. Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Dasgupta T, Wilson LD, Yu JB. A retrospective review of 1349 cases of sebaceous carcinoma. Cancer 2009; 115: 158-65
    CrossrefPubMedGoogle Scholar
  • 2 Khan Z, Misra G, Fiander AN, Dallimore NS. Sebaceous carcinoma of the vulva. Bjog 2003; 110: 227-8
    CrossrefPubMedGoogle Scholar
  • 3 Gay JT, Gross GP. Muir-Torre Syndrome. Treasure Island (FL): StatPearls; 2019
    Google Scholar
  • 4 Harwood CA, Swale VJ, Bataille VA, Quinn AG, Ghali L, Patel SV. et al. An association between sebaceous carcinoma and microsatellite instability in immunosuppressed organ transplant recipients. J Invest Dermatol 2001; 116: 246-53
    CrossrefPubMedGoogle Scholar
  • 5 Cohen PR, Kohn SR, Davis DA, Kurzrock R. Muir-Torre syndrome. Dermatol Clin 1995; 13: 79-89
    CrossrefPubMedGoogle Scholar
  • 6 John AM, Schwartz RA. Muir-Torre syndrome (MTS): An update and approach to diagnosis and management. J Am Acad Dermatol 2016; 74: 558-66
    CrossrefPubMedGoogle Scholar
  • 7 Rulon DB, Helwig EB. Cutaneous sebaceous neoplasms. Cancer 1974; 33: 82-102
    CrossrefPubMedGoogle Scholar
  • 8 Pusiol T, Morichetti D, Zorzi MG. Sebaceous carcinoma of the vulva: Critical approach to grading and review of the literature. Pathologica 2011; 103: 64-7
    PubMedGoogle Scholar
  • 9 Woelber L, Mahner S, Voelker K, Eulenburg CZ, Gieseking F, Choschzick M. et al. Clinicopathological prognostic factors and patterns of recurrence in vulvar cancer. Anticancer Res 2009; 29: 545-52
    Google Scholar
  • 10 Na HY, Choe JY, Shin SA, Choung HK, Oh S, Chung JH. et al. Proposal of a provisional classification of sebaceous carcinoma based on hormone receptor expression and HER2 status. Am J Surg Pathol 2016; 40: 1622-30
    CrossrefPubMedGoogle Scholar
  • 11 Audisio RA, Lodeville D, Quagliuolo V, Clemente C. Sebaceous carcinoma arising from the eyelid and from extra-ocular sites. Tumori 1987; 73: 531-5
    CrossrefPubMedGoogle Scholar
  • 12 Carlson JW, McGlennen RC, Gomez R, Longbella C, Carter J, Carson LF. Sebaceous carcinoma of the vulva: A case report and review of the literature. Gynecol Oncol 1996; 60: 489-91
    CrossrefPubMedGoogle Scholar
  • 13 Thakur BK, Verma S, Khonglah Y, Jitani A. Multifocal sebaceous carcinoma of the vulva. Indian J Dermatol Venereol Leprol 2017; 83: 221-4
    CrossrefPubMedGoogle Scholar
  • 14 Sullivan SA, Tran AQ, O’Connor S, Gehrig PA. Sebaceous carcinoma of the vulva: A case report and review of the literature. Gynecol Oncol Rep 2016; 18: 40-1
    CrossrefPubMedGoogle Scholar
  • 15 Yam P, Namuduri R, Chia Y, Kuei T. Sebaceous carcinoma of the vulva – A rare tumor of vulva. Int J Gynecol Obstet 2012; 119S3: S531-867
    Google Scholar
  • 16 Escalonilla P, Grilli R, Cañamero M, Soriano ML, Fariña MC, Manzarbeitia F. et al. Sebaceous carcinoma of the vulva. Am J Dermatopathol 1999; 21: 468-72
    CrossrefPubMedGoogle Scholar
  • 17 Kawamoto M, Fukuda Y, Kamoi S, Sugisaki Y, Yamanaka N. Sebaceous carcinoma of the vulva. Pathol Int 1995; 45: 767-73
    CrossrefPubMedGoogle Scholar
  • 18 Jacobs DM, Sandles LG, Leboit PE. Sebaceous carcinoma arising from Bowen’s disease of the vulva. Arch Dermatol 1986; 122: 1191-3
    CrossrefPubMedGoogle Scholar
  • 19 Ikuse S, Jinbou A, Matsushima I. A case of sebaceous carcinoma. Jpn J Dermatol 1976; 86: 783
    Google Scholar