CC BY-NC-ND 4.0 · Asian J Neurosurg 2019; 14(04): 1144-1150
DOI: 10.4103/ajns.AJNS_101_19
Original Article

Pediatric brainstem gliomas: An institutional experience

Altaf Laghari
0   Department of Neurosurgery, Aga Khan University Hospital Hospital, Karachi
Mirza Baig
1   Rudy L. Ruggles Biomedical Research Institute, Danbury, Connecticut
Ehsan Bari
0   Department of Neurosurgery, Aga Khan University Hospital Hospital, Karachi
Aneela Darbar
0   Department of Neurosurgery, Aga Khan University Hospital Hospital, Karachi
Naureen Mushtaq
2   Department of Pediatrics, Aga Khan University Hospital Hospital, Karachi
Umm Hani Abdullah
0   Department of Neurosurgery, Aga Khan University Hospital Hospital, Karachi
Daniyal Khan
3   Medical College, Aga Khan University Hospital, Karachi
› Author Affiliations

Objective: The aim of this study was to analyze the clinical profiles and outcomes of pediatric brainstem gliomas treated at our institute. Methodology: We reviewed the files of 18 pediatric age group patients diagnosed with brainstem glioma at our institution. The following variables were recorded: age, sex, duration of symptoms, date of diagnosis, main clinical symptoms, Karnofsky performance status score, magnetic resonance imaging findings, histopathology findings, details of the treatment given, disease progression, and date of mortality/last follow-up. This data were then transferred to SPSS version 23 which was used for further analysis. Results: The mean age of our cohort was 8.6 years (range 3–15). There were 11 (61.1%) males and 7 (38.9%) females. There were 16 (88.9%) patients with diffuse intrinsic pontine gliomas (DIPGs), 1 (5.6%) patients with exophytic medullary gliomas, and 1 (5.6%) patient with midbrain/tectal glioma. Mean overall survival (OS) was 9.7 months. Mean progression-free survival (PFS) was 6.3 months. All patients with DIPG eventually passed away from their disease. Patients with DIPG who received radiotherapy had a longer OS and PFS than those who did not (9.8 and 6 months vs. 3.4 and 2.4 months). Diagnostic latency >1 month was found to have a statistically significant longer progression-free interval. Conclusion: DIPGs in the pediatric population have a poor prognosis. Radiotherapy serves to increase survival time but is not curative.

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Publication History

Article published online:
09 September 2022

© 2019. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (

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