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CC BY-NC-ND 4.0 · Asian J Neurosurg 2020; 15(01): 198-203
DOI: 10.4103/ajns.AJNS_208_19
Case Report

Custom-made hydroxyapatite cranioplasty: Radiological and histological evidence of bone-biomaterial osteointegration in five patients

Zanotti Bruno
Department of Neuroscience, “C. Poma” Hospital, Mantova
,
Nataloni Angelo
1   Department of Clinic, FinCeramica Faenza, RA
,
Spaggiari Riccardo
2   Department od Neurosurgery, Humanitas University, Pieve Emanuele
,
Zingaretti Nicola
3   Department of Medical Science, Clinic of Plastic and Reconstructive Surgery, Academic Hospital of Udine, University of Udine, Udine
,
Pizzolitto Stefano
4   Department of Pathology, Santa Maria della Misericordia University Hospital Udine, Udine
,
Parodi Camillo
3   Department of Medical Science, Clinic of Plastic and Reconstructive Surgery, Academic Hospital of Udine, University of Udine, Udine
,
Nicolosi Federico
5   Department of Neurosurgery, Neurocenter, IRCCS Humanitas Clinical and Research Hospital, Rozzano, MI
,
Morselli Carlotta
6   Department of Neuroscience, Sapienza University of Rome, Rome
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Custom-made cranial implants facilitate the surgical reconstruction of destructive pathologies of the skull or extensive demolitive skull surgery. Customized cranioplasty allows for an immediate restoration of the functional integrity of the cranial defect (restitutio ad integrum), with excellent functional and esthetic outcome and a quick, safe, and simple procedure. In this context, bioceramics like hydroxyapatite (HA) claim high biocompatibility and bone-binding capability. The osteoconductive properties of the HA have been reported in animal models and humans. The purpose of this study is to demonstrate with radiological and histological examination and how HA prosthesis may integrate after their implantation showing data related to five patients that needed primary HA cranial reconstruction with secondary removal after few years. The histological examination showed neo-formed lamellar/trabecular bone tissue fragments accompanied by the amorphous reticular tissue (HA prosthesis) revealing diffuse ossification sites in all included cases.

Key-words:

Cranioplasty - custom made - hydroxyapatite - osteointegration

Financial support and sponsorship

Nil.




Publikationsverlauf

Eingereicht: 09. Juli 2019

Angenommen: 23. Dezember 2019

Artikel online veröffentlicht:
16. August 2022

© 2020. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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