CC BY-NC-ND 4.0 · Asian J Neurosurg 2018; 13(03): 656-659
DOI: 10.4103/ajns.AJNS_259_16
Original Article

Riluzole can improve sensory and motor function in patients with acute spinal cord injury

Ali Meshkini
1   Neuroscience Research Center, Tabriz University of Medical Sciences
,
Firooz Salehpour
2   Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz
,
Javad Aghazadeh
2   Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz
,
Farhad Mirzaei
2   Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz
,
Seyed Naseri Alavi
2   Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz
› Author Affiliations

Background: Spinal cord injury (SCI) causes sensory, motor function and consists of a large proportion of patients that referred to trauma centers. Riluzole blocks the sodium channels and has possible supportive effects on the central nervous system. The aim of this study was to investigate the effect of riluzole on sensory and motor improvement and pain level in patients with acute SCI. Materials and Methods: In this clinical trial, sixty patients with acute SCI with A to C Frankel grade selected and randomly divided into two groups (each group included thirty patients). The two groups carefully matched in terms of age, sex, and Frankel class. Case group, in addition to conventional treatment, received riluzole and was evaluated after 6-week, 3-month, and 6-month periods in terms of sensory and motor status and compared with control group. Results: There were sixty patients divided into case and control groups. In the 6-week follow-up period and 3-month follow-up period, there was no significant difference between the two groups based on sensory and motor function (P = 0.053). In 6-month follow-up period, the difference was significant in case group (P = 0.001). Conclusion: The compressions between two groups demonstrated a significant difference in sensory and motor improvement and reduce pain level in patients with SCI.



Publication History

Article published online:
14 September 2022

© 2018. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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