The loss of dopaminergic neurons from the substantia nigra pars compacta characterizes
the classical pathology of Parkinson's disease (PD). Deep brain stimulation (DBS)
has become an increasingly common treatment for PD. Sometimes excessive tremors due
to exacerbated PD hinder the surgery and may almost make it impossible. This is a
case report highlights use of IV ketamine for intraoperative sedation of a patient
with PD, with severe dyskinesia & tremors, posted for DBS. IV ketamine resulted in
prompt abolition of tremors and dyskinesia, which were unresponsive to previous traditional
sedative drugs.
Key-words:
Deep brain stimulation - dyskinesia - ketamine - Parkinson's disease - sedation