Comparison of osteoclastogenesis and local invasiveness of ameloblastoma and keratocystic odontogenic tumor

Natheer H. Al-Rawi; Ammar K. Al-Siraj; Ahlam H. Majeed

doi:10.4103/ejd.ejd_54_17

European Journal of Dentistry, Table of Contents

CC BY-NC-ND 4.0 · Eur J Dent 2018; 12(01): 036-042
DOI: 10.4103/ejd.ejd_54_17

Original Article

Dental Investigation Society

Comparison of osteoclastogenesis and local invasiveness of ameloblastoma and keratocystic odontogenic tumor

Authors

Natheer H. Al-Rawi

¹Department of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates
Ammar K. Al-Siraj

²Department of Oral Diagnosis, College of Dentistry, University of Baghdad, Baghdad, Iraq
Ahlam H. Majeed

²Department of Oral Diagnosis, College of Dentistry, University of Baghdad, Baghdad, Iraq

Abstract

Abstract:

Objectives The aim of this study was to compare the expression of receptor-activated nuclear factor kappa B (RANK) with its ligand (RANKL) and matrix metalloproteinase-2 (MMP2) in solid/multicystic ameloblastomas (ABs) and keratocystic odontogenic tumors (KOTs). Materials and Methods: The expression of MMP2, RANK, and RANKL molecules was evaluated in 13 ABs and 14 KOTs by immunohistochemistry. The expressions were calculated in the odontogenic epithelial cells as well as the stromal cells. Results: Odontogenic epithelia of AB expressed MMP2, RANK, and RANKL significantly higher than that of KOTs (P < 0.05). The expression of MMP2, RANK, and RANKL was highest in plexiform subtype (79.9%, 81.08%, and 65.1%, respectively). KOTs without daughter epithelia nests expressed both MMP2 and RANK the least (56.06% and 47.5%, respectively). Stromal cells, on the other hand, expressed similar MMP2 pattern in odontogenic epithelia of both AB and KOT. RANKL was expressed weaker in the stromal cells of both lesions. Conclusion: Invasive biological and osteolytic behaviors of both lesions were evaluated in this study. It was found to be more in AB than keratocystic odontogenic. A significant expression of MMP2, RANK, and RANKL in both KOTs associated with microcyst and plexiform type AB as well.

Key words:

Keratocystic odontogenic tumor - matrix metalloproteinase-2 - odontogenic keratocysts - receptor-activated nuclear factor kappa B - receptor-activated nuclear factor kappa B ligand - solid/multicystic ameloblastoma

Full Text

References

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