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CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2020; 12(03): 185-194
DOI: 10.4103/ijmbs.ijmbs_47_20
Original Article

Hematologic, biochemical, and infection biomarker abnormalities associated with COVID-19: A systematic review and meta-analysis

Sara Abdulla
1   Department of Biochemistry, Faculty of Medicine, University of Benghazi, Benghazi
,
Adela Elamami
2   Department of Medicine, Faculty of Medicine, University of Benghazi, Benghazi
,
Hayam Elawamy
3   Department of Medical Laboratory, College of Medical Technology, Benghazi
,
Aisha Muhammed
4   Department of Physiology, Faculty of Medicine, Omar Al-Mukhtar University, El-Beyda
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Objectives: We aimed to analyze the laboratory data of coronavirus disease 2019 (COVID-19) patients for clinical help, to overcome the vulnerabilities of reverse transcription–polymerase chain reaction testing for diagnosing COVID-19, and to reduce the number of negative results when diagnosing, particularly in global regions which are recognized to have limited resources. Materials and Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, the authors performed a systematic literature review, using three databases to assess laboratory data of COVID-19-confirmed cases, and the articles that described significant laboratory irregularities were ultimately chosen. Crosschecking was performed on the references of these articles in order to identify further studies. The statistical software R version 3.6.1 was used for meta-analysis of COVID-19 studies. Results: A total of 13 relevant articles were included. They yielded a total of 2662 individuals who tested positive for COVID-19. The analysis results demonstrated that male patients comprised a more substantial proportion, accounting for 57.9% of the total. The principal laboratory findings of the COVID-19 patients indicated that they commonly had lymphocytopenia 0.943 (confidence interval [CI]: 0.857–1.03), high D-dimer 0.459 (CI: 0.237–0.6808), high procalcitonin 0.089 (CI: 0.066–0.111), high C-reactive protein 17.203 (CI: 6.520–27.886), and high lactate dehydrogenase 278.265 (CI: 238.995–317.535). Conclusions: Infection with COVID-19 is associated with significant laboratory irregularities. The increased focus must be applied to laboratory parameters to quickly identify a large number of infected patients and asymptomatic carriers, prevent virus transmission, and assure timely treatment of patients, particularly in regions characterized by limited resources.

Key-words:

A systematic review - coronavirus disease 2019 - laboratory findings

Financial support and sponsorship

Nil.




Publication History

Received: 06 May 2020

Accepted: 30 July 2020

Article published online:
14 July 2022

© 2020. The Libyan Authority of Scientific Research and Technologyand the Libyan Biotechnology Research Center. All rights reserved. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License,permitting copying and reproductionso long as the original work is given appropriate credit. Contents may not be used for commercial purposes, oradapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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