Download PDF
Open Access
CC BY-NC-ND 4.0 · Ibnosina Journal of Medicine and Biomedical Sciences 2020; 12(03): 153-161
DOI: 10.4103/ijmbs.ijmbs_86_20
Review Article

Femoral neuropathy after kidney transplantation: A literature review of case reports and case series

Authors

  • Jamir Rissardo

    1   Medicine Department, Federal University of Santa Maria, Santa Maria

  • Ana Caprara

    1   Medicine Department, Federal University of Santa Maria, Santa Maria
Further Information
Also available at
  Permissions and Reprints

Kidney transplant (KT) surgery can increase survival probability more than any other transplant. In this context, neurological complications could occur in an important percentage of individuals because this surgery is considered one of the most common organ transplantations. One rare type of neurological complication, which can occur after KT surgery, is the femoral motor neuropathy. We aimed to evaluate the clinical epidemiological profile and pathological mechanisms of femoral motor neuropathy after KT surgery. Relevant reports in six databases were identified and reviewed by two reviewers without language restriction. Seventeen reports of 183 cases from ten countries, more one unpublished case from our institution were assessed. The mean age was 39 years (range 5–69) with male sex (62.5%) and Asiatic origin predominance. The central primary kidney disease leading to renal failure was essential hypertension. The mean time from KT surgery to the onset of femoral neuropathy was 1.78 days, and the time from the occurrence of neuropathy to recovery was 6 months. The incidence of femoral neuropathy after KT surgery was 1.85%. The current review provides four possible mechanisms related to this complication, but maybe these explanations lead to a misunderstanding of the main risk factors for the development of femoral neuropathy. Furthermore, studies with current surgical techniques should be investigated because most of the data come from the old literature. Therefore, prospective studies and reports assessing the graft-recipient ratio and management options should be done.

Key-words:

Femoral nerve - incidence - kidney transplantation - literature review - neuropathy

Financial support and sponsorship

Nil.




Publication History

Received: 10 July 2020

Accepted: 25 August 2020

Article published online:
14 July 2022

© 2020. The Libyan Authority of Scientific Research and Technologyand the Libyan Biotechnology Research Center. All rights reserved. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License,permitting copying and reproductionso long as the original work is given appropriate credit. Contents may not be used for commercial purposes, oradapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Centers for Disease Control and Prevention. Chronic Kidney Disease in the United States. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention; 2019.
  • 2 Mohammadi MH, Salarzaei M, Parooie F. Neurological complications after renal transplantation: A systematic review and meta-analysis. Ther Apher Dial 2019;23:518-28.
  • 3 Saran R, Robinson B, Abbott KC, Agodoa LY, Bhave N, Bragg-Gresham J, et al. US renal data system 2017 annual data report: Epidemiology of kidney disease in the united States. Am J Kidney Dis 2018;71:A7.
  • 4 Hemmersbach-Miller M, Alexander BD, Sudan DL, Pieper C, Schmader KE. Single-center analysis of infectious complications in older adults during the first year after kidney transplantation. Eur J Clin Microbiol Infect Dis 2019;38:141-8.
  • 5 Shoskes A, Wilson R. Neurologic complications of kidney transplantation. Transl Androl Urol 2019;8:164-72.
  • 6 Brouns R, De Deyn PP. Neurological complications in renal failure: A review. Clin Neurol Neurosurg 2004;107:1-6.
  • 7 Piotrowski PC, Lutkowska A, Tsibulski A, Karczewski M, Jagodziński PP. Neurologic complications in kidney transplant recipients. Folia Neuropathol 2017;55:86-109.
  • 8 Jin H, Li C, Yuan Q, Xu L, Li Z, Cai M, et al. Clinical characteristics of neurological complications after renal transplantation. Biomed Res 2017;28:3903-6.
  • 9 Dhar R, Human T. Central nervous system complications after transplantation. Neurol Clin 2011;29:943-72.
  • 10 Sharma KR, Cross J, Santiago F, Ayyar DR, Burke G 3rd. Incidence of acute femoral neuropathy following renal transplantation. Arch Neurol 2002;59:541-5.
  • 11 Kim MH, Jun KW, Hwang JK, Moon IS, Kim JI. Characteristics of femoral motor neuropathies induced after kidney transplantation: A case series. Transplant Proc 2016;48:933-7.
  • 12 Sunderland S. Nerves and Nerve in Juries. 1st ed. Edinburgh: E & S Livingstone; 1968.
  • 13 De Vries E, Schoonvelde M, Schumacher G. No longer lost in translation: Evidence that Google Translate works for comparative bag-of-words text applications. Polit Anal 2018;26:417-30.
  • 14 Van Veer H, Coosemans W, Pirenne J, Monbaliu D. Acute femoral neuropathy: A rare complication after renal transplantation. Transplant Proc 2010;42:4384-8.
  • 15 Li QS, Huo WQ, Nie ZL, Wang HF, Liang PH, Jin FS. Acute femoral neuropathy following renal transplantation: A retrospective, multicenter study in China. Transplant Proc 2010;42:1699-703.
  • 16 Chang I, Kim T. 2327 Incidence of femoral neuropathy after kidney transplantation. Transplant 2008;86:760.
  • 17 Nikoobakht M, Mahboobi A, Saraji A, Mehrsai A, Emamzadeh A, Mahmoudi MT, et al. Pelvic nerve neuropathy after kidney transplantation. Transplant Proc 2007;39:1108-10.
  • 18 Sung DH, Lee KW, Lee YT, Jung JY, Ra YJ. The long term prognosis of postoperative femoral neuropathy. Ann Rehabil Med 2002;26:550-4.
  • 19 Minz M, Sharma S, Sawhney IM, Sakhuja V, Yadav RV. Femoral neuropathy following renal transplantation. Indian J Urol 1996;12:31.
  • 20 Jog MS, Turley JE, Berry H. Femoral neuropathy in renal transplantation. Can J Neurol Sci 1994;21:38-42.
  • 21 Kumar A, Dalela D, Bhandari M, Mishra UK, Kher V, Gupta A. Femoral neuropathy--an unusual complication of renal transplantation. Transplantation 1991;51:1305-6.
  • 22 Meech PR. Femoral neuropathy following renal transplantation. Aust N Z J Surg 1990;60:117-9.
  • 23 Vogels M, Buskens F, de Vries J, de Jong M, Monnens L. Femoral neuropathy after renal transplantation. Int J Pediatr Nephrol 1987;8:55-6.
  • 24 Yazbeck S, Larbrisseau A, O'Regan S. Femoral neuropathy after renal transplantation. J Urol 1985;134:720-1.
  • 25 Vaziri ND, Barton CH, Ravikumar GR, Martin DC, Ness R, Saiki J. Femoral neuropathy: A complication of renal transplantation. Nephron 1981;28:30-1.
  • 26 Sisto D, Chiu WS, Geelhoed GW, Lewis R. Femoral neuropathy after renal transplantation. South Med J 1980;73:1464-6.
  • 27 Pontin AR, Donaldson RA, Jacobson JE. Femoral neuropathy after renal transplantation. S Afr Med J 1978;53:376-8.
  • 28 Vaziri ND, Barnes J, Khosrow M, Ehrlich R, Rosen SM. Compression neuropathy subsequent to renal transplantation. Urology 1976;7:145-7.
  • 29 Gustafson KJ, Pinault GC, Neville JJ, Syed I, Davis JA Jr, Jean-Claude J, et al. Fascicular anatomy of human femoral nerve: Implications for neural prostheses using nerve cuff electrodes. J Rehabil Res Dev 2009;46:973-84.
  • 30 Khanna S, Khanna AK. Clinical anatomy of lower extremity. In: Khanna A, Tiwary S. Ulcers of the Lower Extremity. New Delhi: Springer, 2016.
  • 31 Hsin HT, Hwang JJ. Isolated femoral nerve neuropathy after intra-aortic balloon pump treatment. J Formos Med Assoc 2007;106:S29-32.
  • 32 Boontje AH, Haaxma R. Femoral neuropathy as a complication of aortic surgery. J Cardiovasc Surg (Torino) 1987;28:286-9.
  • 33 Chen SS, Lin AT, Chen KK, Chang LS. Femoral neuropathy after pelvic surgery. Urology 1995;46:575-6.
  • 34 Kvist-Poulsen H, Borel J. Iatrogenic femoral neuropathy subsequent to abdominal hysterectomy: Incidence and prevention. Obstet Gynecol 1982;60:516-20.
  • 35 Pozzati E, Poppi M, Galassi E. Femoral nerve lesion secondary to inguinal herniorrhaphy. Int Surg 1982;67:85-6.
  • 36 Gombar KK, Gombar S, Singh B, Sangwan SS, Siwach RC. Femoral neuropathy: A complication of the lithotomy position. Reg Anesth 1992;17:306-8.
  • 37 Farrell CM, Springer BD, Haidukewych GJ, Morrey BF. Motor nerve palsy following primary total hip arthroplasty. J Bone Joint Surg Am 2005;87:2619-25.
  • 38 Noldus J, Graefen M, Huland H. Major postoperative complications secondary to use of the Bookwalter self-retaining retractor. Urology 2002;60:964-7.
  • 39 Akoh JA, Rana TA, Higgs D. Bilateral psoas haematomata complicating renal transplantation. Surg Res Pract 2014;2014:678979.
  • 40 Young MR, Norris JW. Femoral neuropathy during anticoagulant therapy. Neurology 1976;26:1173-5.
  • 41 Sharma KR, Sriram S, Fries T, Bevan H, Bradley WG. Lurnbosacral radiculoplexopathy as a manifestation of Epstein-Barr virus infection. Neurology 1993;43:2550-4.
  • 42 Brun A, Caviness V, Rudnick P, Tyler HR. Hemorrhages into peripheral nerves in association with leukemia. J Neuropathol Exp Neurol 1964;23:719-25.
  • 43 Laurent LE. Femoral nerve compression syndrome with paresis of the quadriceps muscle caused by radiotherapy of malignant tumours. A report of four cases. Acta Orthop Scand 1975;46:804-8.
  • 44 D'Amelio LF, Musser DJ, Rhodes M. Bilateral femoral nerve neuropathy following blunt trauma. Case report. J Neurosurg 1990;73:630-2.
  • 45 Calverley JR, Mulder DW. Femoral neuropathy. Neurology 1960;10:963-7.
  • 46 Moore AE, Stringer MD. Iatrogenic femoral nerve injury: A systematic review. Surg Radiol Anat 2011;33:649-58.
  • 47 Giglio SR, Schwartzberg GJ. Self Retaining Retractor. Google Patents; 1996.
  • 48 Nicholson M, Windmill D, Horsburgh T, Harris K. Influence of allograft size to recipient body-weight ratio on the long-term outcome of renal transplantation. Br J Surg 2000;87:314-9.
  • 49 Ben-Haim M, Emre S, Fishbein TM, Sheiner PA, Bodian CA, Kim-Schluger L, et al. Critical graft size in adult-to-adult living donor liver transplantation: Impact of the recipient's disease. Liver Transpl 2001;7:948-53.
  • 50 Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, et al. Diabetic neuropathy: A position statement by the american diabetes association. Diabetes Care 2017;40:136-54.
  • 51 Saran R, Robinson B, Abbott KC, Agodoa LY, Albertus P, Ayanian J, et al. US Renal data system 2016 annual data report: Epidemiology of kidney disease in the United States. Am J Kidney Dis 2017;69:A7-8.
  • 52 WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004;363:157-63.
  • 53 Harrison LH Jr, Flye MW, Seigler HF. Incidence of anatomical variants in renal vasculature in the presence of normal renal function. Ann Surg 1978;188:83-9.
  • 54 Khalek M, Swar S, Mohamady T, Boriek M. Efficacy of physical therapy program on femoral neuropathy after renal transplantation. IJTRR 2016;5:205-9.