Subscribe to RSS
Download PDF
DOI: 10.4103/ijmpo.ijmpo_103_18
Primary Rectal Lymphoma with Synchronous Liver Involvement: An Extremely Rare Case Report
Financial support and sponsorship Nil.
Abstract
Both primary rectal lymphoma (PRL) and primary hepatic lymphoma are rare entities, concomitant NHL in rectum and liver is an extremely rare coincidence. Cases of primary colonic lymphoma however can be found in literature. We report an extremely rare case of PRL with synchronous liver involvement after obtaining written informed consent, with a review of available literature. The case was provisionally diagnosed to be an adenocarcinoma of rectum with liver metastasis, with final confirmation on immunohistochemistry. PRL with synchronous liver involvement is an extremely rare coincidence. It is usually confused with more common adenocarcinoma of rectum with liver metastasis posing diagnostic challenges. The optimal management of PRL has never been validated through randomized trials. The treatment options include chemotherapy, radiation, surgical treatment, or a combination of these. Chemotherapeutic agents of choice are the cyclophosphamide, doxorubicin, vincristine, and prednisone regimen, with or without monoclonal antibody rituximab.
Publication History
Received: 03 May 2018
Accepted: 21 June 2018
Article published online:
23 May 2021
© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Zucca E, Roggero E, Bertoni F, Cavalli F. Primary extranodal non-Hodgkin’s lymphomas. Part 1: Gastrointestinal, cutaneous and genitourinary lymphomas. Ann Oncol 1997; 8: 727-37
- 2 Stanojevic GZ, Nestorovic MD, Brankovic BR, Stojanovic MP, Jovanovic MM, Radojkovic MD. et al. Primary colorectal lymphoma: An overview. World J Gastrointest Oncol 2011; 3: 14-8
- 3 Stanojević GZ, Stojanović MP, Stojanović MM, Krivokapić Z, Jovanović MM, Katić VV. et al. Non-Hodgkin’s lymphomas of the large bowel-clinical characteristics, prognostic factors and survival. Acta Chir Iugosl 2008; 55: 109-14
- 4 Cho MJ, Ha CS, Allen PK, Fuller LM, Cabanillas F, Cox JD. et al. Primary non-Hodgkin lymphoma of the large bowel. Radiology 1997; 205: 535-9
- 5 Warnera B, Birda G, Schofielda J, Rassama S. Primary hepatic lymphoma: A diagnosis to remember. J Med Cases 2013; 4: 52-5
- 6 Risio D, Percario R, Legnini M, Caldaralo F, Angelucci D, Marinelli C. et al. Diffuse large B-cell lymphoma of the colon with synchronous liver metastasis: A rare case report mimicking metastatic colorectal adenocarcinoma. BMC Surg 2014; 14: 75
- 7 Peng JX, Wang LZ, Tan ZJ, Zhong XS, Huang YX, Diao JF. et al. Concomitant non-Hodgkin’s lymphoma in colon and liver: Report of a rare case and review of literature. Int J Clin Exp Pathol 2015; 8: 3257-61
- 8 Dawson IM, Cornes JS, Morson BC. Primary malignant lymphoid tumours of the intestinal tract. Report of 37 cases with a study of factors influencing prognosis. Br J Surg 1961; 49: 80-9
- 9 Colomo L, López-Guillermo A, Perales M, Rives S, Martínez A, Bosch F. et al. Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma. Blood 2003; 101: 78-84
- 10 Bilsel Y, Balik E, Yamaner S, Bugra D. Clinical and therapeutic considerations of rectal lymphoma: A case report and literature review. World J Gastroenterol 2005; 11: 460-1