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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2018; 39(02): 206-209
DOI: 10.4103/ijmpo.ijmpo_132_17
Original Article

Epstein–Barr Virus Infection in Adult Patients with Gastric Cancer in Northeast of Iran

Authors

  • Sakineh Amoueian

    Department of Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

  • Armin Attaranzadeh

    Department of Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

  • Zeinab Gholamimoallem

    Department of Hematology and Medical Oncology, Mashhad University of Medical Sciences, Mashhad, Iran

  • Masoud Sadeghi

    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

  • Seyed-Mehdi Hashemi

    Department of Hematology and Medical Oncology, Zahedan University of Medical Sciences, Zahedan, Iran

  • Abolghasem Allahyari

    Department of Hematology and Medical Oncology, Mashhad University of Medical Sciences, Mashhad, Iran

Financial support and sponsorship Nil.
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Abstract

Background: Epstein–Barr virus (EBV) is a DNA virus from human herpes virus that associates with many of the human cancers including gastric cancer (GC). Aims: The aim of the present study was to report infection of EBV in adult patients with GC in Northeast of Iran and the correlation between a number of clinicopathology factors with EBV status. Materials and Methods: In a case–control study in 2016, 56 GC patients and 56 controls were selected for the analysis. All patients had gastric adenocarcinoma untreated patients with age >18 years. EBV status detected by the polymerase chain reaction method. Results: Out of 56 GC patients, 35 (62.5%) were EBV positivity and out of 56 controls 3 (5.4%) were EBV positivity (P < 0.001). There is not a significant correlation between the variables with the EBV status (P > 0.05). Furthermore, the progression-free survival rate for the patients with EBV negativity was 95.2% compared with 82.9% for EBV positivity (P = 0.174). Conclusions: This study reported a very high prevalence of EBV-associated GC in the Northeast of Iran compared with other areas of the World and showed a significant correlation between EBV infection and incidence of GC.

Keywords

Epstein–Barr virus - gastric cancer - polymerase chain reaction - survival


Publication History

Article published online:
23 June 2021

© 2018. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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