Open Access
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(04): 598-600
DOI: 10.4103/ijmpo.ijmpo_133_18
Letter to Editor

Cutaneous Infarcts and Antineutrophil Cytoplasmic Antibody‑Positive Vasculitis in Angioimmunoblastic T‑Cell Lymphoma: A Rare Presentation

Ashwin Mahesh
Department of General Medicine, Army College of Medical Sciences, Delhi Cantt., New Delhi
,
Sandeep Kumar
Department of General Medicine, Army College of Medical Sciences, Delhi Cantt., New Delhi
,
Abhish Mohan
Department of General Medicine, Armed Forces Medical College, Pune, Maharashtra
,
Niket Verma
Department of General Medicine, Army College of Medical Sciences, Delhi Cantt., New Delhi
› Institutsangaben

Financial support and sponsorship Nil.
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Sir,

Angioimmunoblastic T-cell lymphoma (AITL) is a rare and unique subtype of peripheral T-cell lymphoma, accounting for 2%–5% of all non-Hodgkin’s lymphomas.[1] The lymph node architecture is often effaced, with retention of only a few benign follicles. The infiltrate characteristically extends beyond the lymph node capsule, with preserved and dilated subcapsular sinus. Often, there is interfollicular proliferation of endothelial venules. The neoplastic T-cells are positive for CD2, CD3, CD4, CD10, CXCL-13, PD1, and often BCL-6.[2]

AITL is associated with many systemic features such as fever, rash, or arthritis. These systemic features may precede the appearance of other features of lymphoma. The disease may present as autoimmune phenomena, such as the presence of circulating immune complexes, cold agglutinins, hemolytic anemia, and rheumatoid factor and anti-smooth muscle antibodies. Hypergammaglobulinemia is present in approximately 50% of patients, typically polyclonal.[3] Vasculitis is occasionally associated with AITL, but it is usually antineutrophil cytoplasmic antibody (ANCA)-negative vasculitis.[4]



Publikationsverlauf

Eingereicht: 14. Juni 2018

Angenommen: 12. Juli 2019

Artikel online veröffentlicht:
03. Juni 2021

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