PDF icon Download PDF
Open Access
CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(S 01): S70-S76
DOI: 10.4103/ijmpo.ijmpo_141_17
Original Article

Demographic and Clinical Characteristics of Chronic Myeloid Leukemia Patients: A Study on Confined Populations of Southern India

Manjula Gorre
Departments of Biochemistry, University College of Science, Osmania University, Hyderabad, Telangana, India
,
RB Sashidhar
Departments of Biochemistry, University College of Science, Osmania University, Hyderabad, Telangana, India
,
Sandhya Annamaneni
Departments of Genetics, University College of Science, Osmania University, Hyderabad, Telangana, India
,
Raghunadharao Digumarti
Departments of Department of Medical Oncology, Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India
,
Vishnupriya Satti
Departments of Genetics, University College of Science, Osmania University, Hyderabad, Telangana, India
› Author Affiliations
Financial support and sponsorship This work was supported by the UGC-Dr. DS. Kothari Post Doctoral Fellowship Program to Dr. Manjula Gorre (F.4-2/2006 [BSR]/BL/14-15/0150).
› Further Information
Also available ateRef
  Permissions and Reprints
Preview

Abstract

Context: Chronic myeloid leukemia (CML) is one of the most common hematological malignancies in all populations throughout the world. Even though the pathophysiology of CML was well explained in majority of the studies, the incidence of CML was shown to exhibit population diversity, and hence, the demographic factors underlying CML origin remain to be understood. Further, the introduction of tyrosine kinase inhibitors had revolutionized the treatment of CML over the years; however, there is a need for developing tailoring therapy to individual risk since the patient clinical heterogeneity poses a major problem during drug response. Therefore, the study of basic clinical picture may aid in planning treatment strategies for CML patients. Aim: The aim of this article is to study the epidemiological and clinical variables associated with the prognosis of CML. Subjects and Methods: We have considered the distribution of various demographic and clinical variables among 476 CML patients diagnosed at Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India. Statistical Analysis Used: All the analyses were performed through SPSS software (version 21.0). Correlation and Cox regression analyses were also performed. Results: Apart from the elevated male sex ratio in CML incidence, high frequency of males was observed to be nonresponders to imatinib mesylate (IM). IM response was shown to be dependent on phase of diagnosis, whereas overall survival of CML patients depends on the age at onset and response to IM. Conclusions: The study of epidemiology and clinical picture of CML patients may help in planning better treatment strategies at diagnosis to achieve long-term progression-free survival.

Keywords

Chronic myeloid leukemia - clinical variable - epidemiology - imatinib mesylate - survival


Publication History

Article published online:
24 May 2021

© 2019. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India