Abstract
Introduction: The aim of the study was to evaluate the prognostic significance of histopathological
differentiation in treatment outcome of locally advanced carcinoma cervix. Materials and Methods: This retrospective study includes 167 patients of locally advanced carcinoma cervix
treated between January 2006 and December 2008 who have received definitive chemoradiation.
Results:: The number of patients with well (85 [50.9%]) and moderately differentiated (76
[45.5%]) carcinoma was nearly equal with poorly differentiated variety having only
6 (3.6%) patients. On completion of treatment out of the 167 patients, 133 (79.6%)
had a complete response and 34 (20.4%) had residual disease. On mean follow-up of
11 months, 19 (14.2%) patients had local and 5 (3.7%) had a distant relapse. Histopathological
differentiation and age had no association with treatment outcome, whereas early-stage
disease showed trend favoring better treatment response. Conclusion: Advanced stage along with poor histopathological differentiation influences the aggressiveness
of the tumor responsible for distant relapse. However, histopathological differentiation
has no correlation with local treatment response and overall survival. The main factor
influencing the treatment outcome is the intrinsic radiosensitivity of the tumor and
volume of the disease.
Keywords
Carcinoma cervix - histopathological differentiation - intrinsic radiosensitivity
- prognostic factor - treatment outcome
