CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(02): 273-274
DOI: 10.4103/ijmpo.ijmpo_159_18
Practitioner Section

Malignant Hypertension Secondary to Renin-Producing Hepatoblastoma

Doinita Sfrijan
Department of Oncology, Pediatrics Clinic, “Marie Sklodowska Curie” Emergency Clinical Hospital for Children, Bucharest, Romania
,
Cristian Scurtu
Department of Oncology, Pediatrics Clinic, “Marie Sklodowska Curie” Emergency Clinical Hospital for Children, Bucharest, Romania
,
Mihaela Paca
Department of Oncology, Pediatrics Clinic, “Marie Sklodowska Curie” Emergency Clinical Hospital for Children, Bucharest, Romania
,
Dan-Alexandru Iozsa
Pediatic Surgery Clinic, “Marie Sklodowska Curie” Emergency Clinical Hospital for Children, Bucharest, Romania
› Author Affiliations
Financial support and sponsorship Nil.

Abstract

Clinical presentation of hepatoblastoma is often insidious and its paraneoplastic manifestations are not uncommon. We report an extremely rare case of a renin-secreting hepatoblastoma inducing malignant hypertension remarked in our clinic. The hepatic malignancy classified as PRETEXT IV and a multidisciplinary approach according to SIOPEL III was made with a poor outcome. Hepatoblastoma in children should be considered as possible etiology of hypertension in children.



Publication History

Received: 17 July 2018

Accepted: 18 October 2018

Article published online:
23 May 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 Manuprasad A, Radharkrishnan V, Sunil BJ, Ramakrishnan AS, Ganesan TS, Ganesan P. et al. Hepatoblastoma: 16-years’ experience from a tertiary cancer centre in India. Pediatr Hematol Oncol 2018; 3: 13-6
  • 2 Sharma D, Subbarao G, Saxena R. Hepatoblastoma. Semin Diagn Pathol 2017; 34: 192-200
  • 3 Madabhavi I, Patel A, Choudhary M, Aagre S, Revannasiddaiah S, Modi G. et al. Paraneoplastic recurrent hypoglycaemic seizures: An initial presentation of hepatoblastoma in an adolescent male – A rare entity. Case Rep Pediatr 2014; 2014: 104543
  • 4 Moritake H, Taketomi A, Kamimura S, Ikuno Y, Seo Y, Fukuda T. et al. Renin-producing hepatoblastoma. J Pediatr Hematol Oncol 2000; 22: 78-80
  • 5 Tavasoli A, Mehrazma M, Hooman N, Afshar Khas L. Severe hypertension and encephalopathy due to renin-producing hepatoblastoma. Iran J Cancer Prev 2013; 6: 227-30
  • 6 Ranjan A, Mohanlal S, Kondekar A, Kadakia P, Ghildyal R, Wattal S. Dual paraneoplastic syndromes in a case of pediatric hepatoblastoma: A rare and challenging case. Pediatr Educ Res 2017; 5: 97-100
  • 7 Khalifa NM, Mittal R, Khalifa SO. Hypertension and hypoglicemia in a child with hepatoblastoma: A case report. Kuwait Med J 2012; 44: 133-4
  • 8 Flynn JT, Tullus K. Severe hypertension in children and adolescents: Pathophysiology and treatment. Pediatr Nephrol 2009; 27: 503-4