Papillary Tumor of the Pineal Region: A Case with Unique Immunohistochemical Keratin Expression Pattern

Abstract

Papillary tumor of the pineal region (PTPR) is a rare neuroepithelial tumor first described in 2003. It is a newly recognized entity and introduced in the WHO classification of central nervous system tumors in 2007. Till date, about 70 cases have been described in literature. Herein, we report an additional case of PTPR in a 25-year-old male with emphasis on immunohistochemistry and ultrastructural features. Interestingly, this case showed a unique membranous as well as dot-like Golgi zone keratin (AE1/AE3 and CK18) expression pattern.

Keywords

Immunohistochemistry - keratin - papillary tumor - pineal - ultrastructure

• References

• 1 Jouvet A, Fauchon F, Liberski P, Saint-Pierre G, Didier-Bazes M, Heitzmann A. et al. Papillary tumor of the pineal region. Am J Surg Pathol 2003; 27: 505-12
• 2 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. WHO Classification of Tumours of the Central Nervous System Revised. Lyon: IARC 2016; 4: 180-2
• 3 Roncaroli F, Scheithauer BW. Papillary tumor of the pineal region and spindle cell oncocytoma of the pituitary: New tumor entities in the 2007 WHO classification. Brain Pathol 2007; 17: 314-8
• 4 Hasselblatt M, Blümcke I, Jeibmann A, Rickert CH, Jouvet A, van de NesJA. et al. Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal region. Neuropathol Appl Neurobiol 2006; 32: 287-83
• 5 Rickard KA, Parker JR, Vitaz TW, Plaga AR, Wagner S, Parker JCJr. et al. Papillary tumor of the pineal region: Two case studies and a review of the literature. Ann Clin Lab Sci 2011; 41: 174-81
• 6 Fèvre-Montange M, Hasselblatt M, Figarella-Branger D, Chauveinc L, Champier J, Saint-Pierre G. et al. Prognosis and histopathologic features in papillary tumors of the pineal region: A retrospective multicenter study of 31 cases. J Neuropathol Exp Neurol 2006; 65: 1004-11
• 7 Heim S, Beschorner R, Mittelbronn M, Keyvani K, Riemenschneider MJ, Vajtai I. et al. Increased mitotic and proliferative activity are associated with worse prognosis in papillary tumors of the pineal region. Am J Surg Pathol 2014; 38: 106-10