Cutaneous Malignant Melanoma and Targeted Therapy Based on the Biomarkers

Abstract

Malignant melanoma is the most aggressive form of cutaneous malignancy. It accounts for more than 75% of cancer-related deaths among cutaneous malignancies. It accounts for <5% of cutaneous malignancy. Numerous biomarkers are used in malignant melanoma with varying clinical applications, including diagnostic purposes, prognosis, therapeutic purpose, and targeted therapy against melanoma. Systemic chemotherapy in malignant melanoma has little benefit compared to immunotherapy and targeted therapy. The observed overall survival with systemic chemotherapy is much less compared with targeted therapy in advanced or metastatic melanoma. Various targeted therapies are currently used in melanoma treatment including BRAF inhibitors such as vemurafenib and dabrafenib; MEK inhibitors such as trametinib; anti-CTLA-4 antibodies such as ipilimumab; and anti-programmed cell death 1 antibodies such as nivolumab, pembrolizumab, and pidilizumab. This study discusses the role of biomarkers and targeted therapies based on the biomarker.

Keywords

Anti-CRLA-4 antibodies - anti-programmed cell death 1 therapy - biomarkers - BRAF inhibitors - MEK inhibitors - melanoma - targeted therapy

Publikationsverlauf

Eingereicht: 15. September 2018

Angenommen: 04. August 2019

Artikel online veröffentlicht:
03. Juni 2021

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