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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(02): 282-284
DOI: 10.4103/ijmpo.ijmpo_227_18
Practitioner Section

Deluging Thrombosis: An Unusual Presentation of Acute Promyelocytic Leukemia

Aditya Jandial
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Kundan Mishra
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Deepesh Lad
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Shano Naseem
Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Pankaj Malhotra
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Acute promyelocytic leukemia (APML) patients are prone to thrombosis. However, thrombosis at presentation is rare in APML. Our patient presented with thrombosis and cytopenia, and the clinical diagnosis was of paroxysmal nocturnal hemoglobinuria. However, subsequent peripheral blood smear and bone marrow study confirmed the diagnosis of APML. The patient was successfully managed with anticoagulation, arsenic trioxide, and all-trans retinoic acid.

Keywords

Acute promyelocytic leukemia - anti-coagulation - chemotherapy - thrombosis


Publication History

Received: 17 October 2018

Accepted: 20 June 2019

Article published online:
23 May 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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