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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2020; 41(03): 378-380
DOI: 10.4103/ijmpo.ijmpo_24_20
Trainee’s Corner

Epigenetics

Ravi Jaiswal
Department of Medical Oncology, BIACHRI, Hyderabad, Telangana, India
,
Esha Jafa
Department of Medical Oncology, Superspeciality Cancer Centre, Lucknow, Uttar Pradesh, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Historically, cancer is known to be a genetic disease. It is now realized that it involves epigenetic abnormalities along with genetic alterations. Epigenetics is an extra layer of instruction that lies upon DNA and controls how the genes are read and expressed. It simply means changes in phenotype without a change in genotype. In this review we aim to discuss the fundamentals of epigenetics, role of these alterations in carcinogenesis and its implications for epigenetic therapies.

Keywords

Epigenetics - histone deacetylase - myelodysplastic syndrome


Publication History

Received: 26 January 2020

Accepted: 27 May 2020

Article published online:
28 June 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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