Combining Immunotherapy with Multikinase Inhibitors: A Cautious New Promise

Abstract

Immune check point inhibitors have made a sea change in oncology practice in current times. These drugs have crossed the conventional boundaries of histology and organ of origin. Tumor agnostic approvals for mismatch repair deficient, microsatellite-instability (MSI)-H and recently tumor mutational burden-high solid tumors have been a giant leap. The Oncology community seems poised to embrace the concept of “immunotherapy for all.” Recent studies have evaluated the manipulation of tumor-associated macrophages using multi-kinase inhibitors, to make even MSI low tumor responsive to checkpoint inhibitors. With accelerated food and drug administration approvals, the promise of this combo is palpable but definitely merits caution.

Keywords

Immune checkpoint inhibitors - lenvatinib - regorafenib

Publication History

Received: 08 July 2020

Accepted: 05 September 2020

Article published online:
14 May 2021

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