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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2019; 40(04): 521-530
DOI: 10.4103/ijmpo.ijmpo_69_18
Original Article

The Conundrum of Dual Primary Malignancies: Four Years’ Experience of a Single Tertiary Care Institute in India

Niharika Bisht
Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, India
,
Sankalp Singh
Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, India
,
Arti Sarin
Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, India
,
Samir Gupta
Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, India
,
Harinder Pal Singh
Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, India
,
Amul Kapoor
Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, India
,
Deepak Mulajker
Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, India
,
Richa Joshi
Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, India
,
Abhishek Purkayastha
Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, India
,
Prabha Shankar Mishra
Malignant Disease Treatment Centre, Command Hospital (SC), Pune, Maharashtra, India
,
Divya Shelly
Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India
› Author Affiliations Financial support and sponsorship The study was funded by Command Hospital (SC), Wanowrie, Pune, Maharashtra, India.
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Abstract

Background: Encountering more than one malignancy in a cancer patient is no longer uncommon; this increasing incidence is mostly attributable to the improvements in life expectancy, awareness, and diagnostic facilities. This article aims to highlight this institute’s experience in diagnosis and treatment of patients of multiple primary malignancies and a comprehensive review of literature. Materials and Methods: This is a descriptive study of retrospectively collected data of a single institution over 4 years from 2013 to 2016. Known cases of cancer who were diagnosed with a second primary malignancy were included in the study. Various details such as age, sex, site of disease, temporal relation of two cancers (synchronous or metachronous), family history, tobacco use, treatment given, and survival at 1 year were recorded, organized in a tabular form, analyzed, and described. Results: A total of 29 cases of dual malignancies comprising 0.74% of a total of 3879 patients of cancer were encountered. Seventy-two percent of the cases were metachronous and 5 years was the mean time interval between tumors. There was a female preponderance, and the average age was 56 years. Breast was the most common site of malignancy. At 1 year from diagnosis of second primary, 69% of the patients were alive and 27% were disease-free. Conclusion: Second primary in a patient of cancer is becoming increasingly common and the suspicion of the same should always be borne in mind during follow-up. Prognosis as well as intent of treatment depends on respective stages of the two malignancies.

Keywords

Dual malignancy - metachronous - synchronous


Publication History

Received: 25 March 2018

Accepted: 21 June 2018

Article published online:
03 June 2021

© 2020. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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