Open Access
CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2018; 28(01): 123-131
DOI: 10.4103/ijri.IJRI_257_17
Breast Imaging

Sonographic features of invasive ductal breast carcinomas predictive of malignancy grade

Kanika Gupta
Departments of Radiodiagnosis, ESI Medical College and PGIMSR, Chennai, Tamil Nadu, India
,
Meenakshisundaram Kumaresan
Departments of Pathology, ESI Medical College and PGIMSR, Chennai, Tamil Nadu, India
,
Bhuvaneswari Venkatesan
Departments of Radiodiagnosis, ESI Medical College and PGIMSR, Chennai, Tamil Nadu, India
,
Tushar Chandra
Departments of Community Medicine, ESI Medical College and PGIMSR, Chennai, Tamil Nadu, India
,
Aruna Patil
Departments of Obstetrics and Gynecology, ESI Medical College and PGIMSR, Chennai, Tamil Nadu, India
,
Maya Menon
Department of Radiology, University of Central Florida, Orlando, USA
› Author Affiliations

Subject Editor:
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Abstract

Context: Assessment of individual sonographic features provides vital clues about the biological behavior of breast masses and can assist in determining histological grade of malignancy and thereby prognosis. Aims: Assessment of individual sonographic features of biopsy proven invasive ductal breast carcinomas as predictors of malignancy grade. Settings and Design: A retrospective analysis of sonographic findings of 103 biopsy proven invasive ductal breast carcinomas. Materials and Methods: Tumor characteristics on gray-scale ultrasound and color flow were assessed using American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) Atlas Fifth Edition. The sonographic findings of masses were individually correlated with their histopathologic grades. Statistical Analysis Used: Chi square test, ordinal regression, and Goodman and Kruskal tau test. Results: Breast mass showing reversal/lack of diastolic flow has a high probability of belonging to histological high grade tumor (β 1.566, P 0.0001). The masses with abrupt interface boundary are more likely grade 3 (β 1.524, P 0.001) in comparison to masses with echogenic halos. The suspicious calcifications present in and outside the mass is a finding associated with histologically high grade tumors. The invasive ductal carcinomas (IDCs) with complex solid and cystic echotexture are more likely to be of high histological grade (β 1.146, P 0.04) as compared to masses with hypoechoic echotexture. Conclusions: Certain ultrasound features are associated with tumor grade on histopathology. If the radiologist is cognizant of these sonographic features, ultrasound can be a potent modality for predicting histopathological grade of IDCs of the breast, especially in settings where advanced tests such as receptor and molecular analyses are limited.



Publication History

Article published online:
26 July 2021

© 2018. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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