CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2017; 27(03): 286-289
DOI: 10.4103/ijri.IJRI_440_16
Neuroradiology & Head and Neck Imaging

Serial brain MRI findings in a rare survivor of rabies encephalitis

Akhilesh Rao
Department of Radiodiagnosis and Imaging, Command Hospital (CC), Lucknow, Uttar Pradesh, India
,
Yayati Pimpalwar
Department of Radiodiagnosis and Imaging, Command Hospital (CC), Lucknow, Uttar Pradesh, India
,
Arindam Mukherjee
Department of Neurology, Command Hospital (CC), Lucknow, Uttar Pradesh, India
,
Neha Yadu
Department of Radiodiagnosis and Imaging, Command Hospital (CC), Lucknow, Uttar Pradesh, India
› Author Affiliations
Financial support and sponsorship Nil.

Abstract

Rabies is a neurotropic viral illness, almost always fatal, that is equally dreaded by healthcare practitioners and patients due to the dismal prognosis and limited treatment options once symptoms set in. There are hardly any reports on MRI changes in the brain in survivors of rabies encephalitis. We present the clinical course and the imaging findings on serial MRI examinations in a rare patient who survived rabies infection. Initial brain MRI done 8 days after onset of symptoms revealed bilaterally symmetrical non-enhancing areas of T1 and T2 hyperintensity in the basal ganglia, thalami, mid brain, and pons along with T2 hyperintensity and restricted diffusion in fronto-parietal cortical grey matter and left hippocampus. Subsequent MRI scans at 2 months and 5 months revealed progressive brain atrophy, leukoencephalopathy, and gliosis.



Publication History

Article published online:
27 July 2021

© 2017. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 
  • References

  • 1 Netravathia M, Udanib V, Mani RS, Gadad V, Ashwini MA, Bhat M, et al. Unique clinical and imaging findings in a first ever documented PCR positive rabies survival patient: A case report. J Clin Virol 2015;70:83-8.
  • 2 Bulletin of the World Health Organization 2014;92:230.
  • 3 Mrak RE, Young L. Rabies encephalitis in humans: Pathology, pathogenesis and pathophysiology. J Neuropathol Exp Neurol 1994;53:1-10.
  • 4 Sing TM, Soo MY. Imaging findings in rabies. Australas Radiol 1996;40:338-41.
  • 5 Rao AS, Varma DR, Chalapathi Rao MV, Mohandas S. Case report: Magnetic resonance imaging in rabies encephalitis. Indian J Radiol Imaging 2009;19:301-4.
  • 6 Pleasure SJ, Fischbein NJ. Correlation of clinical and neuroimaging findings in a case of rabies encephalitis. Arch Neurol 2000;57:1765-9.
  • 7 Awasthi M, Parmar H, Patankar T, Castillo M. Imaging findings in rabies encephalitis. AJNR Am J Neuroradiol 2001;22:677-80.
  • 8 Laothamatas J, Hemachudha T, Mitrabhakdi E, Wannakrairot P, Tulayadaechanont S. MR Imaging in Human Rabies. AJNR Am J Neuroradiol 2003;24:1102-9.
  • 9 Jassi P, Attri A, Dhawan R, Kakkar C, Saggar K. MR imaging in rabies encephalitis: A rare entity. Ann Indian Acad Neurol 2016;19:125-8.