Phenotypes of high-density lipoprotein cholesterol and their relationship with glycemic status in type 2 diabetic patients

Chikezie Onwukwe; Nkiru Chikezie; Kalu Okorie; Augustine Ohwovoriole

doi:10.4103/jdep.jdep_4_21

Journal of Diabetes and Endocrine Practice, Table of Contents

CC BY-NC-ND 4.0 · Journal of Diabetes and Endocrine Practice 2021; 04(02): 59-63
DOI: 10.4103/jdep.jdep_4_21

Original Article

Phenotypes of high-density lipoprotein cholesterol and their relationship with glycemic status in type 2 diabetic patients

Chikezie Onwukwe

¹Division of Endocrinology and Diabetes, Al Isawiya General Hospital, Ministry of Health, Directorate of Gurayat

,

Nkiru Chikezie

²Public Health Specialist, Department of Community Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra

,

Kalu Okorie

³Consultant Cardiologist, Department of Medicine, Cedarcrest Hospitals, Gudu, Abuja

,

Augustine Ohwovoriole

⁴Professor of Medicine and Consultant Endocrinologist, College of Medicine, University of Lagos, Lagos, Nigeria

› Author Affiliations

Abstract

Background: There are varying reports on the association of high-density lipoprotein cholesterol (HDL-C) phenotypes and glycemia in type 2 diabetes mellitus (T2D) patients. Such information is lacking in Nigerian data. Aim: The aim of this study was to determine the relationship between HDL-C phenotypes and glycemic control in T2D patients. Materials and Methods: Clinical and laboratory data were collected from consenting T2D patients. Information was managed and analyzed with appropriate software. Results: Four hundred T2D patients consisting of 235 and 165 persons with and without poor glycemic control, respectively, were recruited for this study. There was a significant negative correlation between glycosylated hemoglobin (HbA1c) and the HDL₂-C phenotype (r_s = −0.12, P = 0.01). The correlation between HbA1c and the HDL₃-C phenotype was not statistically significant (r_s = −0.06, P = 0.21). Conclusion: The HDL₂ phenotype has a stronger correlation with glycemic status than the HDL₃ phenotype in T2D patients.

Keywords

Glycemic control - high-density lipoprotein - phenotype

Full Text

References

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