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CC BY-NC-ND 4.0 · South Asian J Cancer 2018; 07(03): 207-209
DOI: 10.4103/sajc.sajc_176_17
ORIGINAL ARTICLE: Neuroendocrine Tumors

Clinical profile and treatment outcomes of metastatic neuroendocrine carcinoma: A single institution experience

Autor*innen

  • K. N. Lokesh

    Department of Medical Oncology Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

  • Abhishek Anand

    Department of Medical Oncology Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

  • K. C. Lakshmaiah

    Department of Medical Oncology Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

  • K. Govind Babu

    Department of Medical Oncology Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

  • Dasappa Lokanatha

    Department of Medical Oncology Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

  • Linu Abraham Jacob

    Department of Medical Oncology Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

  • M. C. Suresh Babu

    Department of Medical Oncology Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

  • A.H. Rudresha

    Department of Medical Oncology Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

  • L.K. Rajeev

    Department of Medical Oncology Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

  • Smitha C. Saldanha

    Department of Medical Oncology Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

  • G.V. Giri

    Department of Medical Oncology Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

  • Dipti Panwar

    Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

  • Deepak Koppaka

    Department of Medical Oncology Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

  • Rajesh Patidar

    Department of Medical Oncology Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

Source of Support: Nill.
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Abstract

Background: Neuroendocrine carcinoma (NEC) is a rare tumor arising from the diffuse neuroendocrine system. Most of these present in the advanced stage and palliative chemotherapy remains the only option. The prognosis remains poor with the standard chemotherapy regimen of platinum and etoposide (EP) providing modest survival benefit. Methods: The study was done for 3 years at a tertiary cancer center in South India. Patients with a diagnosis of metastatic NEC were analyzed for clinical and pathological characteristics. The treatment outcomes and prognostic factors were evaluated using appropriate statistical test. Results: A total of 114 patients of metastatic NEC satisfied the inclusion criteria and were analyzed. Gastrointestinal including hepatobiliary tract (33%) was the most common site of primary disease followed by lung (26%), genitourinary (15%), head and neck (14%), and unknown primary (9%). On analysis of pattern of metastasis, liver (65%) was the most common site followed by bone (54%) and lung (42%). The median overall survival was 11 months with a statistically significant difference between pulmonary and extrapulmonary disease (8 vs. 13 months; P = 0.003). Ki67% value was strongly associated with prognosis (hazard ratio 0.517, 95% confidence interval; 0.318–0.840, P = 0.008) whereas age, sex, and lactate dehydrogenase level did not show any relation with survival. Conclusion: The outcome of advanced NEC with standard chemotherapy remains poor. Larger studies with other therapeutic and novel agents are warranted to improve the treatment outcomes.

Key words

Ki67 - neuroendocrine carcinoma - survival


Publikationsverlauf

Artikel online veröffentlicht:
22. Dezember 2020

© 2018. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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