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Hamostaseologie 2014; 34(01): 9-19
DOI: 10.5482/HAMO-13-09-0051
Review
Schattauer GmbH

Rhythm outcomes after catheter ablation of atrial fibrillation

Clinical implication of biomarkersRhythmuskontrolle nach Katheterablation von VorhofflimmernDie klinische Bedeutung der Biomarker
J. Kornej
1   University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom
2   Heart Center Department of Electrophysiology, University of Leipzig, Germany
,
D. Husser
2   Heart Center Department of Electrophysiology, University of Leipzig, Germany
,
A. Bollmann
2   Heart Center Department of Electrophysiology, University of Leipzig, Germany
,
G. Y. H. Lip
1   University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom
› Author AffiliationsDr. Kornej is supported by the German Cardiac Society St. Jude Medical Stipend.
Further Information

Publication History

received: 09 September 2013

accepted in revised form: 21 October 2013

Publication Date:
27 December 2017 (online)

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Summary

Atrial fibrillation (AF) occurs as the result of numerous complex physiological processes in the atria leading to AF promotion and maintenance. Improved diagnostic techniques have identified various biomarkers which may play an important role in the prediction of AF related outcomes (cardio- and cerebrovascular events, as well as mortality and rhythm outcomes). Biomarkers refer to ‘biological markers’ and biomarkers in blood, urine as well as imaging marker (eg, dimensions (left atrial diameter and volume), anatomical features (left appendage and pulmonary vein anatomy), and physiological pattern (LAA flow velocity)) may play important role(s) as clinically important indices in relation to outcomes after different therapeutic strategies. However, the main domain in the biomarker field has focused on bloodbased biomarkers, which are widely used to predict therapeutic success regarding underlying pathophysiological mechanism, such as inflammation, fibrosis, endothelial damage. This review provides an update of the role of clinically relevant biomarkers in AF, with particular focus on AF rhythm outcomes.

Zusammenfassung

Verschiedene komplexe pathophysiologische Prozesse führen zu Vorhofflimmern (VHF). In den letzten Jahren konnten verschiedene Biomarker identifiziert werden, die eine Bedeutung zur Vorhersage von Morbidität (z. B. kardiovaskuläre Ereignisse), Mortalität und Rhythmuserhalt erlangen könnten. Dabei spielen Marker der Inflammation, Fibrose und endothelialen Dysfunktion ein besondere Rolle. Da diese Prozesse wesentlich den Erfolg des Rhythmuserhaltes z. B. nach Katheterablation beeinflussen, soll diese Übersichtsarbeit den aktuellen Wissenstand zu Biomarkern bei Vorhofflimmern und im speziellen zum Erhalt des Sinusrhythmus zusammenfassen und mögliche klinische Anwendungen aufzeigen.

Keywords

Atrial fibrillation - catheter ablation - recurrence - biomarkers

Schlüsselwörter

Vorhofflimmern - Katheterablation - Rezidive - Biomarker
 

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