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DOI: 10.5935/1984-0063.20170025
Prevalence and Predictors of Arrhythmia in Patients with Obstructive Sleep Apnea
Autoren
Objectives To assess the prevalence and types of arrhythmias in Saudi OSA patients and to identify predictors of arrhythmia in this group of patients.
METHODS This case-control study included all patients who underwent level I attended overnight polysomnography between 2009 and 2012. Electrocardiographic data collected during sleep studies of patients with and without OSA were manually reviewed.
Results The study comprised 498 patients (394 OSA patients and 104 non-OSA patients (controls). The prevalence of arrhythmia in OSA patients was higher than that in the controls (26.9% vs. 11.5%; p=0.001). Comparing OSA patients and controls showed: premature atrial contraction (10.2%vs.2.9%;p=0.019), premature ventricular contraction (PVC) (19.3%vs.9.6%;p=0.02), non-isolated PVC (bi/tri/qua) 10.8%vs.2.3%;p=0.04) and atrial fibrillation (1.6%vs.0%;p=0.001). Multiple logistic regression analysis revealed that, patients with OSA had twice the odds of having any cardiac arrhythmia (OR 1.91; CI 95% 1.27-3.11; p <0.05).
Conclusions Patients with OSA had a higher prevalence of arrhythmia compared to controls, and OSA is a predictor of arrhythmia during sleep.
Publikationsverlauf
Eingereicht: 25. Mai 2017
Angenommen: 31. August 2017
Artikel online veröffentlicht:
11. Oktober 2023
© 2023. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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REFERENCES
- 1 Patel N, Donahue C, Shenoy A, Patel A, El-Sherif N. Obstructive sleep apnea and arrhythmia: A systemic review. Int J Cardiol. 2017;228:967-70.
- 2 May AM, Van Wagoner DR, Mehra R. OSA and Cardiac Arrhythmogenesis: Mechanistic Insights. Chest. 2017;151(1):225-41.
- 3 Hersi AS. Obstructive sleep apnea and cardiac arrhythmias. Ann Thorac Med. 2010;5(1):10-7.
- 4 Gottlieb DJ, Yenokyan G, Newman AB, O’Connor GT, Punjabi NM, Quan SF, et al. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation. 2010;122(4):352-60.
- 5 Redline S, Yenokyan G, Gottlieb DJ, Shahar E, O’Connor GT, Resnick HE, et al. Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med. 2010;182(2):269-77.
- 6 Ramos AR, Guilliam D, Dib SI, Koch S. Race/ethnic differences in obstructive sleep apnea risk in patients with acute ischemic strokes in south Florida. Sleep Breath. 2014;18(1):165-8.
- 7 Scharf SM, Seiden L, DeMore J, Carter-Pokras O. Racial differences in clinical presentation of patients with sleep-disordered breathing. Sleep Breath. 2004;8(4):173-83.
- 8 Ancoli-Israel S, Stepnowsky C, Dimsdale J, Marler M, Cohen-Zion M, Johnson S. The effect of race and sleep-disordered breathing on nocturnal BP “dipping”: analysis in an older population. Chest. 2002;122(4):1148-55.
- 9 Pandi-Perumal SR, Abumuamar AM, Spence DW, Chattu VK, Moscovitch A, BaHammam AS. Racial/Ethnic and Social Inequities in Sleep Medicine: The Tip of the Iceberg? J Natl Med Assoc. 2017. [in press].
- 10 Alharbi M, Almutairi A, Alotaibi D, Alotaibi A, Shaikh S, Bahammam AS. The prevalence of asthma in patients with obstructive sleep apnoea. Prim Care Respir J. 2009;18(4):328-30.
- 11 Alotair H, Bahammam A. Gender differences in Saudi patients with obstructive sleep apnea. Sleep Breath. 2008;12(4):323-9.
- 12 Berry RB, Brooks R, Gamaldo CE, Harding SM, Lloyd RM, Marcus CL, et al. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, Version 2.1. www.aasmnet.org, Darien: American Academy of Sleep Medicine; 2014.
- 13 Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, et al. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. J Clin Sleep Med. 2016;12(6):829-37.
- 14 Mehra R, Stone KL, Varosy PD, Hoffman AR, Marcus GM, Blackwell T, et al. Nocturnal Arrhythmias across a spectrum of obstructive and central sleep-disordered breathing in older men: outcomes of sleep disorders in older men (MrOS sleep) study. Arch Intern Med. 2009;169(12):1147-55.
- 15 Mansukhani MP, Wang S, Somers VK. Sleep, death, and the heart. Am J Physiol Heart Circ Physiol. 2015;309(5):H739-49.
- 16 Mehra R, Benjamin EJ, Shahar E, Gottlieb DJ, Nawabit R, Kirchner HL, et al. Association of nocturnal arrhythmias with sleep-disordered breathing: The Sleep Heart Health Study. Am J Respir Crit Care Med. 2006;173(8):910-6.
- 17 Lavergne F, Morin L, Armitstead J, Benjafield A, Richards G1, Woehrle H. Atrial fibrillation and sleep-disordered breathing. J Thorac Dis. 2015;7(12):E575-84.
- 18 Raghuram A, Clay R, Kumbam A, Tereshchenko LG, Khan A. A systematic review of the association between obstructive sleep apnea and ventricular arrhythmias. J Clin Sleep Med. 2014;10(10):1155-60.
- 19 Verrier RL, Josephson ME. Impact of sleep on arrhythmogenesis. Circ Arrhythm Electrophysiol. 2009;2(4):450-9.
- 20 Flemons WW, Remmers JE, Gillis AM. Sleep apnea and cardiac arrhythmias. Is there a relationship? Am Rev Respir Dis. 1993;148(3):618-21.
- 21 Daly MD, Angell-James JE, Elsner R. Role of carotid-body chemoreceptors and their reflex interactions in bradycardia and cardiac arrest. Lancet. 1979;1(8119):764-7.
- 22 Madden BP, Shenoy V, Dalrymple-Hay M, Griffiths T, Millard J, Backhouse L, et al. Absence of bradycardic response to apnea and hypoxia in heart transplant recipients with obstructive sleep apnea. J Heart Lung Transplant. 1997;16(4):394-7.
- 23 Somers VK, Dyken ME, Mark AL, Abboud FM. Parasympathetic hyperresponsiveness and bradyarrhythmias during apnoea in hypertension. Clin Auton Res. 1992;2(3):171-6.
- 24 Becker H, Brandenburg U, Peter JH, Von Wichert P. Reversal of sinus arrest and atrioventricular conduction block in patients with sleep apnea during nasal continuous positive airway pressure. Am J Respir Crit Care Med. 1995;151(1):215-8.
- 25 Koehler U, Schäfer H. Is obstructive sleep apnea (OSA) a risk factor for myocardial infarction and cardiac arrhythmias in patients with coronary heart disease (CHD)? Sleep. 1996;19(4):283-6.
- 26 Koehler U, Fus E, Grimm W, Pankow W, Schäfer H, Stammnitz A, et al. Heart block in patients with obstructive sleep apnoea: pathogenetic factors and effects of treatment. Eur Respir J. 1998;11(2):434-9.
- 27 Koehler U, Becker HF, Grimm W, Heitmann J, Peter JH, Schäfer H. Relations among hypoxemia, sleep stage, and bradyarrhythmia during obstructive sleep apnea. Am Heart J. 2000;139(1 Pt 1):142-8.
- 28 Guilleminault C, Connolly SJ, Winkle RA. Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol. 1983;52(5):490-4.
