CC BY-NC 4.0 · Arch Plast Surg 2015; 42(05): 532-543
DOI: 10.5999/aps.2015.42.5.532
Review Article

Capsular Contracture after Breast Augmentation: An Update for Clinical Practice

Hannah Headon
King's College London Medical School, London, UK
,
Adbul Kasem
Oncoplastic Breast Surgeon Medway NHS Trust, Kent, UK
,
Kefah Mokbel
Aesthetic and Reconstructive Breast Surgery, The London Breast Institute, London, UK
› Author Affiliations

Capsular contracture is the most common complication following implant based breast surgery and is one of the most common reasons for reoperation. Therefore, it is important to try and understand why this happens, and what can be done to reduce its incidence. A literature search using the MEDLINE database was conducted including search terms 'capsular contracture breast augmentation', 'capsular contracture pathogenesis', 'capsular contracture incidence', and 'capsular contracture management', which yielded 82 results which met inclusion criteria. Capsular contracture is caused by an excessive fibrotic reaction to a foreign body (the implant) and has an overall incidence of 10.6%. Risk factors that were identified included the use of smooth (vs. textured) implants, a subglandular (vs. submuscular) placement, use of a silicone (vs. saline) filled implant and previous radiotherapy to the breast. The standard management of capsular contracture is surgical via a capsulectomy or capsulotomy. Medical treatment using the off-label leukotriene receptor antagonist Zafirlukast has been reported to reduce severity and help prevent capsular contracture from forming, as has the use of acellular dermal matrices, botox and neopocket formation. However, nearly all therapeutic approaches are associated with a significant rate of recurrence. Capsular contracture is a multifactorial fibrotic process the precise cause of which is still unknown. The incidence of contracture developing is lower with the use of textured implants, submuscular placement and the use of polyurethane coated implants. Symptomatic capsular contracture is usually managed surgically, however recent research has focussed on preventing capsular contracture from occurring, or treating it with autologous fat transfer.



Publication History

Received: 08 March 2015

Accepted: 13 April 2015

Article published online:
05 May 2022

© 2015. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonCommercial License, permitting unrestricted noncommercial use, distribution, and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes. (https://creativecommons.org/licenses/by-nc/4.0/)

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  • References

  • 1 Johnson M. Breast implants: history, safety, and imaging. Radiol Technol 2013; 84: 439M-515M
  • 2 Namnoum JD, Largent J, Kaplan HM. et al. Primary breast augmentation clinical trial outcomes stratified by surgical incision, anatomical placement and implant device type. J Plast Reconstr Aesthet Surg 2013; 66: 1165-1172
  • 3 Siggelkow W, Faridi A, Spiritus K. et al. Histological analysis of silicone breast implant capsules and correlation with capsular contracture. Biomaterials 2003; 24: 1101-1109
  • 4 Daniels AU. Silicone breast implant materials. Swiss Med Wkly 2012; 142: w13614
  • 5 Handel N, Cordray T, Gutierrez J. et al. A long-term study of outcomes, complications, and patient satisfaction with breast implants. Plast Reconstr Surg 2006; 117: 757-767
  • 6 Wolfram D, Rainer C, Niederegger H. et al. Cellular and molecular composition of fibrous capsules formed around silicone breast implants with special focus on local immune reactions. J Autoimmun 2004; 23: 81-91
  • 7 Prantl L, Poppl N, Horvat N. et al. Serologic and histologic findings in patients with capsular contracture after breast augmentation with smooth silicone gel implants: is serum hyaluronan a potential predictor?. Aesthetic Plast Surg 2005; 29: 510-518
  • 8 Spear SL, Baker Jr JL. Classification of capsular contracture after prosthetic breast reconstruction. Plast Reconstr Surg 1995; 96: 1119-1123
  • 9 Spear SL, Murphy DK. Allergan Silicone Breast Implant U. S. Core Clinical Study Group Natrelle round silicone breast implants: Core Study results at 10 years. Plast Reconstr Surg 2014; 133: 1354-1361
  • 10 Blount AL, Martin MD, Lineberry KD. et al. Capsular contracture rate in a low-risk population after primary augmentation mammaplasty. Aesthet Surg J 2013; 33: 516-521
  • 11 Stutman RL, Codner M, Mahoney A. et al. Comparison of breast augmentation incisions and common complications. Aesthetic Plast Surg 2012; 36: 1096-1104
  • 12 Codner MA, Mejia JD, Locke MB. et al. A 15-year experience with primary breast augmentation. Plast Reconstr Surg 2011; 127: 1300-1310
  • 13 Sevin A, Sevin K, Senen D. et al. Augmentation mammaplasty: retrospective analysis of 210 cases. Aesthetic Plast Surg 2006; 30: 651-654
  • 14 Gutowski KA, Mesna GT, Cunningham BL. Saline-filled breast implants: a Plastic Surgery Educational Foundation multicenter outcomes study. Plast Reconstr Surg 1997; 100: 1019-1027
  • 15 Puckett CL. On the safety of silicone gel breast implants. Cancer Invest 2000; 18: 285
  • 16 Steiert AE, Boyce M, Sorg H. Capsular contracture by silicone breast implants: possible causes, biocompatibility, and prophylactic strategies. Med Devices (Auckl) 2013; 6: 211-218
  • 17 Tan KT, Wijeratne D, Shih B. et al. Tumour necrosis factor-alpha expression is associated with increased severity of periprosthetic breast capsular contracture. Eur Surg Res 2010; 45: 327-332
  • 18 Prantl L, Angele P, Schreml S. et al. Determination of serum fibrosis indexes in patients with capsular contracture after augmentation with smooth silicone gel implants. Plast Reconstr Surg 2006; 118: 224-229
  • 19 Brazin J, Malliaris S, Groh B. et al. Mast cells in the periprosthetic breast capsule. Aesthetic Plast Surg 2014; 38: 592-601
  • 20 Moyer KE, Ehrlich HP. Capsular contracture after breast reconstruction: collagen fiber orientation and organization. Plast Reconstr Surg 2013; 131: 680-685
  • 21 Persichetti P, Segreto F, Carotti S. et al. Oestrogen receptor-alpha and -beta expression in breast implant capsules: experimental findings and clinical correlates. J Plast Reconstr Aesthet Surg 2014; 67: 308-315
  • 22 Wolfram D, Rabensteiner E, Grundtman C. et al. T regulatory cells and TH17 cells in peri-silicone implant capsular fibrosis. Plast Reconstr Surg 2012; 129: 327e-337e
  • 23 Momoh AO, Chung KC. Discussion. T regulatory cells and TH17 cells in peri-silicone implant capsular fibrosis. Plast Reconstr Surg 2012; 129: 338e-339e
  • 24 Smalley DL, Shanklin DR, Hall MF. Monocyte-dependent stimulation of human T cells by silicon dioxide. Pathobiology 1998; 66: 302-305
  • 25 Ojo-Amaize EA, Conte V, Lin HC. et al. Silicone-specific blood lymphocyte response in women with silicone breast implants. Clin Diagn Lab Immunol 1994; 1: 689-695
  • 26 Ulrich D, Lichtenegger F, Eblenkamp M. et al. Matrix metalloproteinases, tissue inhibitors of metalloproteinases, aminoterminal propeptide of procollagen type III, and hyaluronan in sera and tissue of patients with capsular contracture after augmentation with Trilucent breast implants. Plast Reconstr Surg 2004; 114: 229-236
  • 27 Katzel EB, Koltz PF, Tierney R. et al. The impact of Smad3 loss of function on TGF-beta signaling and radiation-induced capsular contracture. Plast Reconstr Surg 2011; 127: 2263-2269
  • 28 Kuhn MA, Wang X, Payne WG. et al. Tamoxifen decreases fibroblast function and downregulates TGF(beta2) in dupuytren's affected palmar fascia. J Surg Res 2002; 103: 146-152
  • 29 Mikulec AA, Hanasono MM, Lum J. et al. Effect of tamoxifen on transforming growth factor beta1 production by keloid and fetal fibroblasts. Arch Facial Plast Surg 2001; 3: 111-114
  • 30 Marques M, Brown SA, Cordeiro ND. et al. Effects of fibrin, thrombin, and blood on breast capsule formation in a preclinical model. Aesthet Surg J 2011; 31: 302-309
  • 31 Kyle DJ, Harvey AG, Shih B. et al. Identification of molecular phenotypic descriptors of breast capsular contracture formation using informatics analysis of the whole genome transcriptome. Wound Repair Regen 2013; 21: 762-769
  • 32 Wolfram D, Oberreiter B, Mayerl C. et al. Altered systemic serologic parameters in patients with silicone mammary implants. Immunol Lett 2008; 118: 96-100
  • 33 Marques M, Brown SA, Cordeiro ND. et al. Effects of coagulase-negative staphylococci and fibrin on breast capsule formation in a rabbit model. Aesthet Surg J 2011; 31: 420-428
  • 34 Tamboto H, Vickery K, Deva AK. Subclinical (biofilm) infection causes capsular contracture in a porcine model following augmentation mammaplasty. Plast Reconstr Surg 2010; 126: 835-842
  • 35 Drinane JJ, Bergman RS, Folkers BL. et al. Revisiting Triple Antibiotic Irrigation of Breast Implant Pockets: a Placebo-controlled Single Practice Cohort Study. Plast Reconstr Surg Glob Open 2013; 1: e55
  • 36 Spear SL, Jespersen MR. Breast implants: saline or silicone?. Aesthet Surg J 2010; 30: 557-570
  • 37 Bengtson BP, Van Natta BW, Murphy DK. et al. Style 410 highly cohesive silicone breast implant core study results at 3 years. Plast Reconstr Surg 2007; 120: 40S-48S
  • 38 Maxwell GP, Van Natta BW, Murphy DK. et al. Natrelle style 410 form-stable silicone breast implants: core study results at 6 years. Aesthet Surg J 2012; 32: 709-717
  • 39 Heden P, Bone B, Murphy DK. et al. Style 410 cohesive silicone breast implants: safety and effectiveness at 5 to 9 years after implantation. Plast Reconstr Surg 2006; 118: 1281-1287
  • 40 Cunningham B. The Mentor Core Study on Silicone MemoryGel Breast Implants. Plast Reconstr Surg 2007; 120: 19S-29S
  • 41 Hammond DC, Migliori MM, Caplin DA. et al. Mentor Contour Profile Gel implants: clinical outcomes at 6 years. Plast Reconstr Surg 2012; 129: 1381-1391
  • 42 Walker PS, Walls B, Murphy DK. Natrelle saline-filled breast implants: a prospective 10-year study. Aesthet Surg J 2009; 29: 19-25
  • 43 El-Sheikh Y, Tutino R, Knight C. et al. Incidence of capsular contracture in silicone versus saline cosmetic augmentation mammoplasty: a meta-analysis. Can J Plast Surg 2008; 16: 211-215
  • 44 Barnsley GP, Sigurdson LJ, Barnsley SE. Textured surface breast implants in the prevention of capsular contracture among breast augmentation patients: a meta-analysis of randomized controlled trials. Plast Reconstr Surg 2006; 117: 2182-2190
  • 45 Wong CH, Samuel M, Tan BK. et al. Capsular contracture in subglandular breast augmentation with textured versus smooth breast implants: a systematic review. Plast Reconstr Surg 2006; 118: 1224-1236
  • 46 Hakelius L, Ohlsen L. A clinical comparison of the tendency to capsular contracture between smooth and textured gel-filled silicone mammary implants. Plast Reconstr Surg 1992; 90: 247-254
  • 47 Schaub TA, Ahmad J, Rohrich RJ. Capsular contracture with breast implants in the cosmetic patient: saline versus silicone--a systematic review of the literature. Plast Reconstr Surg 2010; 126: 2140-2149
  • 48 Poeppl N, Schreml S, Lichtenegger F. et al. Does the surface structure of implants have an impact on the formation of a capsular contracture?. Aesthetic Plast Surg 2007; 31: 133-139
  • 49 Stevens WG, Nahabedian MY, Calobrace MB. et al. Risk factor analysis for capsular contracture: a 5-year Sientra study analysis using round, smooth, and textured implants for breast augmentation. Plast Reconstr Surg 2013; 132: 1115-1123
  • 50 Abramo AC, De Oliveira VR, Ledo-Silva MC. et al. How texture-inducing contraction vectors affect the fibrous capsule shrinkage around breasts implants?. Aesthetic Plast Surg 2010; 34: 555-560
  • 51 Jacombs A, Tahir S, Hu H. et al. In vitro and in vivo investigation of the influence of implant surface on the formation of bacterial biofilm in mammary implants. Plast Reconstr Surg 2014; 133: 471e-480e
  • 52 Minami E, Koh IH, Ferreira JC. et al. The composition and behavior of capsules around smooth and textured breast implants in pigs. Plast Reconstr Surg 2006; 118: 874-884
  • 53 Hall-Findlay EJ. Breast implant complication review: double capsules and late seromas. Plast Reconstr Surg 2011; 127: 56-66
  • 54 Pompei S, Arelli F, Labardi L. et al. Breast reconstruction with polyurethane implants: preliminary report. Eur J Plast Surg 2012; 35: 441-447
  • 55 Vazquez G, Pellon A. Polyurethane-coated silicone gel breast implants used for 18 years. Aesthetic Plast Surg 2007; 31: 330-336
  • 56 Bucky LP, Ehrlich HP, Sohoni S. et al. The capsule quality of saline-filled smooth silicone, textured silicone, and polyurethane implants in rabbits: a long-term study. Plast Reconstr Surg 1994; 93: 1123-1131
  • 57 Henriksen TF, Fryzek JP, Holmich LR. et al. Surgical intervention and capsular contracture after breast augmentation: a prospective study of risk factors. Ann Plast Surg 2005; 54: 343-351
  • 58 Pereira Leite L, Correia Sa I, Marques M. Etiopathogenesis and treatment of breast capsular contracture. Acta Med Port 2013; 26: 737-745
  • 59 Cunningham B, McCue J. Safety and effectiveness of Mentor's MemoryGel implants at 6 years. Aesthetic Plast Surg 2009; 33: 440-444
  • 60 Little G, Baker Jr JL. Results of closed compression capsulotomy for treatment of contracted breast implant capsules. Plast Reconstr Surg 1980; 65: 30-33
  • 61 Forster NA, Kunzi W, Giovanoli P. The reoperation cascade after breast augmentation with implants: what the patient needs to know. J Plast Reconstr Aesthet Surg 2013; 66: 313-322
  • 62 Adams Jr WP. Capsular contracture: what is it? What causes it? How can it be prevented and managed?. Clin Plast Surg 2009; 36: 119-126
  • 63 Lee HK, Jin US, Lee YH. Subpectoral and precapsular implant repositioning technique: correction of capsular contracture and implant malposition. Aesthetic Plast Surg 2011; 35: 1126-1132
  • 64 Maxwell GP, Gabriel A. The neopectoral pocket in revisionary breast surgery. Aesthet Surg J 2008; 28: 463-467
  • 65 Maxwell GP, Birchenough SA, Gabriel A. Efficacy of neopectoral pocket in revisionary breast surgery. Aesthet Surg J 2009; 29: 379-385
  • 66 Castello MF, Lazzeri D, Silvestri A. et al. Maximizing the use of precapsular space and the choice of implant type in breast augmentation mammaplasty revisions: review of 49 consecutive procedures and patient satisfaction assessment. Aesthetic Plast Surg 2011; 35: 828-838
  • 67 Salgarello M, Visconti G, Farallo E. Autologous fat graft in radiated tissue prior to alloplastic reconstruction of the breast: report of two cases. Aesthetic Plast Surg 2010; 34: 5-10
  • 68 Sarfati I, Ihrai T, Kaufman G. et al. Adipose-tissue grafting to the post-mastectomy irradiated chest wall: preparing the ground for implant reconstruction. J Plast Reconstr Aesthet Surg 2011; 64: 1161-1166
  • 69 Roca GB, Graf R, da Silva Freitas R. et al. Autologous fat grafting for treatment of breast implant capsular contracture: a study in pigs. Aesthet Surg J 2014; 34: 769-775
  • 70 Cheng A, Lakhiani C, Saint-Cyr M. Treatment of capsular contracture using complete implant coverage by acellular dermal matrix: a novel technique. Plast Reconstr Surg 2013; 132: 519-529
  • 71 Schmitz M, Bertram M, Kneser U. et al. Experimental total wrapping of breast implants with acellular dermal matrix: a preventive tool against capsular contracture in breast surgery?. J Plast Reconstr Aesthet Surg 2013; 66: 1382-1389
  • 72 Kornstein A. Porcine-derived acellular dermal matrix in primary augmentation mammoplasty to minimize implant-related complications and achieve an internal mastopexy: a case series. J Med Case Rep 2013; 7: 275
  • 73 Hester Jr TR, Ghazi BH, Moyer HR. et al. Use of dermal matrix to prevent capsular contracture in aesthetic breast surgery. Plast Reconstr Surg 2012; 130: 126S-136S
  • 74 Hille-Betz U, Kniebusch N, Wojcinski S. et al. Breast reconstruction and revision surgery for implant-associated breast deformities using porcine acellular dermal matrix: a multicenter study of 156 cases. Ann Surg Oncol 2015; 22: 1146-1152
  • 75 Bastos EM, Sabino Neto M, Garcia EB. et al. Effect of zafirlukast on capsular contracture around silicone implants in rats. Acta Cir Bras 2012; 27: 1-6
  • 76 Spano A, Palmieri B, Taidelli TP. et al. Reduction of capsular thickness around silicone breast implants by zafirlukast in rats. Eur Surg Res 2008; 41: 8-14
  • 77 Reid RR, Greve SD, Casas LA. The effect of zafirlukast (Accolate) on early capsular contracture in the primary augmentation patient: a pilot study. Aesthet Surg J 2005; 25: 26-30
  • 78 Schlesinger SL, Ellenbogen R, Desvigne MN. et al. Zafirlukast (Accolate): a new treatment for capsular contracture. Aesthet Surg J 2002; 22: 329-336
  • 79 Scuderi N, Mazzocchi M, Fioramonti P. et al. The effects of zafirlukast on capsular contracture: preliminary report. Aesthetic Plast Surg 2006; 30: 513-520
  • 80 Scuderi N, Mazzocchi M, Rubino C. Effects of zafirlukast on capsular contracture: controlled study measuring the mammary compliance. Int J Immunopathol Pharmacol 2007; 20: 577-584
  • 81 Mazzocchi M, Dessy LA, Alfano C. et al. Effects of zafirlukast on capsular contracture: long-term results. Int J Immunopathol Pharmacol 2012; 25: 935-944
  • 82 Kim YS, Hong JW, Yoon JH. et al. Botulinum toxin a affects early capsule formation around silicone implants in a rat model. Ann Plast Surg 2015; 74: 488-495
  • 83 Lee SD, Yi MH, Kim DW. et al. The effect of botulinum neurotoxin type A on capsule formation around silicone implants: the in vivo and in vitro study. Int Wound J. 07.03.2014. [Epub] 10.1111/iwj.12228
  • 84 Lee SG, Lee SD, Kim MK. et al. Effect of antiadhesion barrier solution and fibrin on capsular formation after silicone implant insertion in a white rat model. Aesthetic Plast Surg 2015; 39: 162-170
  • 85 Lew DH, Yoon JH, Hong JW. et al. Efficacy of antiadhesion barrier solution on periimplant capsule formation in a white rat model. Ann Plast Surg 2010; 65: 254-258
  • 86 Shin KC, Chung KI, Park BY. et al. The effect of antiadhesion agent on peri-implant capsular formation in rabbits. Ann Plast Surg 2013; 71: 600-604
  • 87 Ye X, Shokrollahi K, Rozen WM. et al. Anaplastic large cell lymphoma (ALCL) and breast implants: breaking down the evidence. Mutat Res Rev Mutat Res 2014; 762: 123-132
  • 88 Miranda RN, Aladily TN, Prince HM. et al. Breast implant-associated anaplastic large-cell lymphoma: long-term follow-up of 60 patients. J Clin Oncol 2014; 32: 114-120
  • 89 Peters W. Update on anaplastic large cell lymphoma in women with breast implants. Plast Surg (Oakv) 2014; 22: 267-269
  • 90 Thompson PA, Prince HM. Breast implant-associated anaplastic large cell lymphoma: a systematic review of the literature and mini-meta analysis. Curr Hematol Malig Rep 2013; 8: 196-210
  • 91 Lazzeri D, Zhang YX, Huemer GM. et al. Capsular contracture as a further presenting symptom of implant-related anaplastic large cell lymphoma. Am J Surg Pathol 2012; 36: 1735-1736