Exercise Training Plus Sildenafil Treatment: Role on Autonomic and Inflammatory Markers

Luis Antonio B. Leoni; Andre R. Fukushima; Leandro Y. Rocha; Daniele J. Feriani; Hélio José Coelho Júnior; Bruno B. Gambassi; Cristiano T. Mostarda; Laura Beatriz Mesiano Maifrino; Bruno Rodrigues

doi:10.1055/a-0633-9132

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2018; 39(10): 749-756
DOI: 10.1055/a-0633-9132

Physiology & Biochemistry

Exercise Training Plus Sildenafil Treatment: Role on Autonomic and Inflammatory Markers

Luis Antonio B. Leoni

¹Human Movement Laboratory, Universidade Sao Judas Tadeu, Sao Paulo, Brazil

,

Andre R. Fukushima

¹Human Movement Laboratory, Universidade Sao Judas Tadeu, Sao Paulo, Brazil

,

Leandro Y. Rocha

¹Human Movement Laboratory, Universidade Sao Judas Tadeu, Sao Paulo, Brazil

²Exercise Physiology Applied to Diseases Research Group, School of Physical Education, Universidade Estadual de Campinas, Campinas, Brazil

,

Daniele J. Feriani

²Exercise Physiology Applied to Diseases Research Group, School of Physical Education, Universidade Estadual de Campinas, Campinas, Brazil

,

Hélio José Coelho Júnior

²Exercise Physiology Applied to Diseases Research Group, School of Physical Education, Universidade Estadual de Campinas, Campinas, Brazil

,

Bruno B. Gambassi

¹Human Movement Laboratory, Universidade Sao Judas Tadeu, Sao Paulo, Brazil

²Exercise Physiology Applied to Diseases Research Group, School of Physical Education, Universidade Estadual de Campinas, Campinas, Brazil

,

Cristiano T. Mostarda

³Dept de Educação Física, Universidade Federal do Maranhão, São Luís, Brazil

,

Laura Beatriz Mesiano Maifrino

⁴Laboratory of Morfoquantitative and Immunohistochemistry Analysis, Sao Judas Tadeu University, Sao Paulo, Brazil

,

Bruno Rodrigues

¹Human Movement Laboratory, Universidade Sao Judas Tadeu, Sao Paulo, Brazil

› Author Affiliations

Abstract

The current study aimed to determine the effects of sildenafil-associated aerobic exercise training (ET) on the physical performance, hemodynamic, autonomic and inflammatory parameters of rats. Male Wistar rats were randomly assigned to: sedentary rats placebo-treated (SP); sedentary rats sildenafil-treated (SS); trained rats placebo-treated (TP); and trained rats sildenafil-treated (TS). Sildenafil treatment consisted of 8 weeks of daily oral gavage (1.5 mg/kg), one hour before the session of ET (60–75% of maximal running speed, 5 days/week, for 8 weeks). After ET period, physical capacity, hemodynamic, autonomic and skeletal muscle inflammatory profile were assessed. Chronic sildenafil treatment causes an additional increase of physical capacity in aerobically trained rats. However, these beneficial effects were accompanied by unwanted alterations, as increased of arterial pressure and peripheral sympathetic modulation, as well as exacerbated inflammatory status on skeletal muscle of rats. Taken together, these data suggest the positive and negative effects of sildenafil chronic administration, associated to aerobic ET, at doses used in clinical practice. This report stresses the importance of paying greater attention to the indiscriminate use of this substance in high-performance sports.

Key words

aerobic training - phosphodiesterase-5 inhibition - blood pressure - autonomic nervous system - inflammation

Full Text

References

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