Abstract
Objective The goal of this study was to clarify the changes and clinical significance of thromboelastography
(TEG) parameters in papillary thyroid carcinomas and nodular goiters.
Methods 62 nodular goiter (NG) patients and 53 papillary thyroid carcinoma (PTC) patients
were included. Coagulation indicators, together with a series of TEG parameters were
collected and analyzed, compared with results of 61 healthy controls (HC). Correlation
analysis was conducted between routine coagulation indicators and TEG parameters.
ROC curves were used to evaluate the potential diagnosis value of the TEG parameters
that were altered in papillary thyroid carcinoma patients.
Results APTT and PT in papillary thyroid carcinoma group were statistically significant higher
than that in control group (p<0.05). MPV was found to be higher in PTC than NG and
healthy controls.
R, K and SP levels were significantly lower in PTC group than that in HC group; Angle,
CI and TPI levels were significantly higher in PTC group than that in HC group. Areas
under the ROC curve of CI, TPI, and angle were 0.725, 0.714, and 0.687 for distinguishing
PTC from HC, 0.662, 0.668 and 0.591 for distinguishing PTC from NG.
Conclusion TEG parameters are altered and indicate hypercoagulablilty status of papillary thyroid
carcinoma patients; CI, TPI, and angle could be potential diagnosis indicators for
detecting papillary thyroid carcinoma.
Key words
thromboelastography - papillary thyroid carcinoma - nodular goiter - diagnosis
