Therapiesteuerung der COPD durch eosinophile Granulozyten?

Helgo Magnussen

doi:10.1055/a-0748-8856

DMW - Deutsche Medizinische Wochenschrift, Table of Contents

Dtsch Med Wochenschr 2019; 144(13): 917-921
DOI: 10.1055/a-0748-8856

Standpunkt

Therapiesteuerung der COPD durch eosinophile Granulozyten?

Ansätze zur personalisierten Medizin bei obstruktiven Atemwegserkrankungen Therapy control of COPD by Eosinophilic Granulocytes?

Authors

Helgo Magnussen

Abstract

Symptomatic patients with COPD reporting about repeated exacerbations in their history (group D according to GOLD recommendations) are treated with dual bronchodilation (LAMA/LABA) with potential benefits from additional ICS. Eosinophils in peripheral blood are considered as potential biomarkers to predict exacerbations. > 300 cells/µL or 4 % of eosinophils in peripheral blood are recommended to treat the patients with additional ICS. In clinical practice, about 10 – 15 % of patients with COPD are classified as group D according to GOLD. < 20 % have increased eosinophils in peripheral blood. Thus, ICS therapy should be restricted to a minority of patients with COPD

Schwerpunkt der medikamentösen Therapie der symptomatischen COPD sind langwirksame Anticholinergika (LAMA) und langwirksame β₂-Symphatikomimetika (LABA). Zusätzlich können bei symptomatischen Patienten mit gehäuften Exazerbationen inhalative Kortikosteroide hilfreich sein. Welche Patienten darauf ansprechen, lässt sich möglicherweise mithilfe einer erhöhten Eosinophilen-Zahl im peripheren Blut vorhersagen.

Schlüsselwörter

COPD - inhalative Kortikosteroide (ICS) - eosinophile Granulozyten

Key words

COPD - inhaled corticosteroids - eosinophils

Full Text

References

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