Zirkulierende Tumorzellen, zirkulierende Tumor-DNA und zirkulierende microRNA beim metastasierten Mammakarzinom – oder: Welche Rolle spielt die Liquid Biopsy beim Brustkrebs?

Arkadius Polasik; Marie Tzschaschel; Fabienne Schochter; Ameli de Gregorio; Thomas W. P. Friedl; Brigitte Rack; Andreas Hartkopf; Peter A. Fasching; Andreas Schneeweiss; Volkmar Müller; Jens Huober; Wolfgang Janni; Tanja Fehm

doi:10.1055/a-0787-7840

TumorDiagnostik & Therapie, Table of Contents

TumorDiagnostik & Therapie 2018; 39(10): 657-664
DOI: 10.1055/a-0787-7840

Thieme Onkologie aktuell

Zirkulierende Tumorzellen, zirkulierende Tumor-DNA und zirkulierende microRNA beim metastasierten Mammakarzinom – oder: Welche Rolle spielt die Liquid Biopsy beim Brustkrebs?

Circulating tumour cells, circulating tumour DNA and circulating MicroRNA in metastatic breast carcinoma – what is the role of liquid biopsy in breast cancer?

Arkadius Polasik

¹Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Ulm, Ulm

,

Marie Tzschaschel

¹Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Ulm, Ulm

,

Fabienne Schochter

¹Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Ulm, Ulm

,

Ameli de Gregorio

¹Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Ulm, Ulm

,

Thomas W. P. Friedl

¹Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Ulm, Ulm

,

Brigitte Rack

¹Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Ulm, Ulm

,

Andreas Hartkopf

²Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Tübingen, Tübingen

,

Peter A. Fasching

³Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Erlangen, Erlangen

,

Andreas Schneeweiss

⁴Nationales Centrum für Tumorerkrankungen, Universitätsklinikum Heidelberg, Heidelberg

,

Volkmar Müller

⁵Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Hamburg-Eppendorf, Hamburg

,

Jens Huober

¹Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Ulm, Ulm

,

Wolfgang Janni

¹Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Ulm, Ulm

,

Tanja Fehm

⁶Klinik für Gynäkologie und Geburtshilfe, Heinrich-Heine-Universität Düsseldorf, Düsseldorf

› Author Affiliations

Abstract

Zusammenfassung

Die Streuung von Tumorzellen und Entstehung solider Metastasen findet sowohl über das Lymph- als auch das Blutsystem statt. Der Nachweis zirkulierender Tumorzellen (CTCs) und der zirkulierenden Tumor-DNA (ctDNA) im venösen Blut ist sowohl beim frühen als auch beim metastasierten Mammakarzinom möglich. Ihre prognostische Relevanz wurde bereits mehrfach bewiesen. Dabei ist die repetitive Untersuchung der CTCs bzw. ctDNA im Sinne einer regelmäßigen „liquid biopsy“ jederzeit und problemlos möglich. Durch die zusätzlichen molekularen Analysen ist es möglich, Tumorcharakteristika und ihre Heterogenität, die mit möglichen Resistenzen einhergehen, zu definieren. Dies ermöglicht den Einsatz einer personalisierten und zielgerichteten Therapie, um neben einem verlängerten Gesamtüberleben auch die Verbesserung der Lebensqualität zu erreichen.

Abstract

Dissemination of tumour cells and the development of solid metastases occurs via blood vessels and lymphatics. Circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA) can be detected in venous blood in patients with early and metastatic breast cancer, and their prognostic relevance has been demonstrated on numerous occasions. Repeated testing for CTCs and ctDNA, or regular so-called “liquid biopsy”, can be performed easily at any stage during the course of disease. Additional molecular analysis allows definition of tumour characteristics and heterogeneity that may be associated with treatment resistance. This in turn makes personalised, targeted treatments possible that may achieve both improved overall survival and quality of life.

Schlüsselwörter

Brust - Her‑2/neu (humaner epidermaler Wachstumsfaktor‑Rezeptor) - Hormonrezeptor - Tumor der Brustdrüse - Metastase

Key words

breast - her‑2/neu (human epidermal growth factor receptor) - hormonal receptor - mammary gland tumor - metastasis

Full Text

References

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