Dtsch Med Wochenschr 2019; 144(22): 1553-1560
DOI: 10.1055/a-0832-5727
Dossier
© Georg Thieme Verlag KG Stuttgart · New York

Interventionelle Behandlung der Mitralklappe – was gibt es Neues 2019?

Interventional Treatment of the Mitral Valve – An Update 2019
Maria Isabel Körber
,
Roman Pfister
,
Stephan Baldus
Further Information

Publication History

Publication Date:
28 October 2019 (online)

Abstract

Mitral regurgitation (MR) is one of the most common valvular defects in the eldery. In patients suffering from heart failure, secondary MR is common and associated with worse prognosis. Due to the usually very high operative risk these patients are immensely under-treated. This leads to an increased need for interventional treatment strategies. Until now there were no randomized data regarding the prognostic impact of interventional treatment of secondary MR. This article is supposed to sum up evidence derived from recent studies regarding this issue. Finally we will provide an outlook on catheter-based mitral valve prothesis.

Die Mitralklappeninsuffizienz ist bei älteren Patienten der häufigste Klappenfehler. Aufgrund des hohen operativen Risikos dieser Patienten besteht allerdings eine erhebliche Unterversorgung. Interventionelle Rekonstruktionsverfahren mit niedrigem Prozedurrisiko könnten eine Option sein. Doch wie ist die Datenlage dazu?

 
  • Literatur

  • 1 Dziadzko V, Clavel MA, Dziadzko M. et al. Outcome and undertreatment of mitral regurgitation: a community cohort study. Lancet (London, UK) 2018; 391: 960-969
  • 2 Michler RE, Smith PK, Parides MK. et al. Two-Year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation. N Engl J Med 2016; 374: 1932-1941
  • 3 Feldman T, Foster E, Glower DD. et al. Percutaneous repair or surgery for mitral regurgitation. N Engl J Med 2011; 364: 1395-1406
  • 4 Maisano F, Franzen O, Baldus S. et al. Percutaneous mitral valve interventions in the real world: Early and 1-year results from the ACCESS-EU, A prospective, multicenter, nonrandomized post-approval study of the Mitraclip therapy in Europe. J Am Coll Cardiol 2013; 62: 1052-1061
  • 5 Baumgartner H, Falk V, Bax JJ. ESC Scientific Document Group.. et al. 2017 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J 2017; 38: 2739-2791
  • 6 Maisano F, Taramasso M, Nickenig G. et al. Cardioband, a transcatheter surgical-like direct mitral valve annuloplasty system: early results of the feasibility trial. Eur Heart J 2016; 37: 817-825
  • 7 Nickenig G, Schueler R, Dager A. et al. Treatment of Chronic Functional Mitral Valve Regurgitation With a Percutaneous Annuloplasty System. J Am Coll Cardiol 2016; 67: 2927-2936
  • 8 Schofer J, Siminiak T, Haude M. et al. Percutaneous Mitral Annuloplasty for Functional Mitral Regurgitation. Circulation 2009; 120: 326-333
  • 9 Siminiak T, Wu JC, Haude M. et al. Treatment of functional mitral regurgitation by percutaneous annuloplasty: results of the TITAN Trial. Eur J Heart Fail 2012; 14: 931-938
  • 10 Rossi A, Dini FL, Faggiano P. et al. Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy. Heart 2011; 97: 1675-1680
  • 11 Obadia JF, Messika-Zeitoun D, Leurent G. MITRA-FR Investigators. et al. Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation. N Engl J Med 2018; 379: 2297-2306
  • 12 Stone GW, Lindenfeld J, Abraham WT. COAPT Investigators. et al. Transcatheter Mitral-Valve Repair in Patients with Heart Failure. N Engl J Med 2018; 379: 2307-2318
  • 13 Grayburn PA, Foster E, Sangli C. et al. Relationship Between the Magnitude of Reduction in Mitral Regurgitation Severity and Left Ventricular and Left Atrial Reverse Remodeling After MitraClip Therapy. Circulation 2013; 128: 1667-1674
  • 14 Messika-Zeitoun D, Nickenig G, Latib A. et al. Transcatheter mitral valve repair for functional mitral regurgitation using the Cardioband system: 1 year outcomes. Eur Heart J 2019; 40: 466-472
  • 15 Praz F, Spargias K, Chrissoheris M. et al. Compassionate use of the PASCAL transcatheter mitral valve repair system for patients with severe mitral regurgitation: a multicentre, prospective, observational, first-in-man study. Lancet (London, UK) 2017; 390: 773-780
  • 16 Pfister R, Hausleiter J, Boekstegers P. et al. Role of percutaneous edge-to-edge repair in secondary mitral regurgitation after MITRA-FR and COAPT. Clin Res Cardiol 2019; DOI: 10.1007/s00392-019-01457-3.
  • 17 Iliadis C, Lee S, Kuhr K. et al. Functional status and quality of life after transcatheter mitral valve repair: a prospective cohort study and systematic review. Clin Res Cardiol 2017; 106: 1005-1017
  • 18 Sorajja P, Mack M, Vemulapalli S. et al. Initial Experience With Commercial Transcatheter Mitral Valve Repair in the United States. J Am Coll Cardiol 2016; 67: 1129-1140
  • 19 Paradis JM, Del Trigo M, Puri R. et al. Transcatheter Valve-in-Valve and Valve-in-Ring for Treating Aortic and Mitral Surgical Prosthetic Dysfunction. J Am Coll Cardiol 2015; 66: 2019-2037
  • 20 Guerrero M, Dvir D, Himbert D. et al. Transcatheter Mitral Valve Replacement in Native Mitral Valve Disease With Severe Mitral Annular Calcification: Results From the First Multicenter Global Registry. JACC Cardiovasc Interv 2016; 9: 1361-1371