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Exp Clin Endocrinol Diabetes 2020; 128(11): 737-744
DOI: 10.1055/a-0883-4955
Article

Altered Brain Regional Homogeneity in First-Degree Relatives of Type 2 Diabetics: A functional MRI Study

Yiyong Liu
1   Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou, China
,
Lin Shi
3   Department of Imaging and Interventional Radiology, Research Centre for Medical Image Computing, The Chinese University of Hong Kong, China
4   Chow Yuk Ho Technology Centre for Innovative Medicine, The Chinese University of Hong Kong, China
,
Xiubao Song
2   Department of Rehabilitation, the First Affiliated Hospital of Jinan University, Guangzhou, China
,
Changzheng Shi
1   Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou, China
,
Wutao Lou
3   Department of Imaging and Interventional Radiology, Research Centre for Medical Image Computing, The Chinese University of Hong Kong, China
,
Dong Zhang
1   Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou, China
,
Alan D. Wang
5   Auckland Bioengineering Institute, and Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
6   Shenzhen SmartView MedTech Limited, Shenzhen, China
,
Liangping Luo
1   Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou, China
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Abstract

Objective This study aimed to investigate regional homogeneity in the first-degree relatives of type 2 diabetes patients.

Methods Seventy-eight subjects, including 26 type 2 diabetes patients, 26 first-degree relatives, and 26 healthy controls, were assessed. All participants underwent resting-state functional magnetic resonance imaging scanning. The estimated regional homogeneity value was used to evaluate differences in brain activities.

Results In first-degree relatives, we observed significantly decreased regional homogeneity in the left anterior cingulate cortex, left insula, and bilateral temporal lobes, and increased regional homogeneity in the left superior frontal gyrus, right anterior cingulate cortex, and bilateral posterior cingulate cortex compared to healthy controls. In type 2 diabetes patients, we detected altered regional homogeneity in the left anterior cingulate cortex, left insula, bilateral posterior cingulate cortex, and several other brain regions compared to healthy controls. Both first-degree relatives and type 2 diabetes patients showed decreased regional homogeneity in the left superior temporal gyrus, right middle temporal gyrus, left anterior cingulate cortex, left insula, and increased regional homogeneity in the left superior frontal gyrus and bilateral posterior cingulate cortex.

Conclusion These findings suggest that altered regional homogeneity in the left anterior cingulate cortex, left insula, left superior frontal gyrus, bilateral posterior cingulate cortex, and bilateral temporal lobes might be a neuroimaging biomarker of type 2 diabetes -related brain dysfunction.

Key words

first-degree relatives - type 2 diabetes - cognitive performance - resting-state functional magnetic resonance imaging - regional homogeneity

* The authors contributed equally to this work.




Publication History

Received: 11 December 2018
Received: 21 March 2019

Accepted: 25 March 2019

Article published online:
28 May 2019

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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