Tanshinone II A Affects Diabetic Peripheral Neuropathic Pain via Spinal Dorsal Horn Neuronal Circuitry by Modulating Endoplasmic Reticulum Stress Pathways

Dawei Kong; Zhuangli Guo; Wenqiang Yang; Qi Wang; Yanbing Yu; Li Zhang

doi:10.1055/a-0919-4614

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2020; 128(01): 59-65
DOI: 10.1055/a-0919-4614

Article

Tanshinone II A Affects Diabetic Peripheral Neuropathic Pain via Spinal Dorsal Horn Neuronal Circuitry by Modulating Endoplasmic Reticulum Stress Pathways

Dawei Kong

¹Department of Neurosurgery, Peking University, China-Japan Friendship School of Clinical Medicine, Beijing, China

,

Zhuangli Guo

²Department of Rehabilitation, The Affiliated Hospital of Qingdao University, Qingdao, China

,

Wenqiang Yang

¹Department of Neurosurgery, Peking University, China-Japan Friendship School of Clinical Medicine, Beijing, China

,

Qi Wang

¹Department of Neurosurgery, Peking University, China-Japan Friendship School of Clinical Medicine, Beijing, China

,

Yanbing Yu‡

¹Department of Neurosurgery, Peking University, China-Japan Friendship School of Clinical Medicine, Beijing, China

,

Li Zhang‡

¹Department of Neurosurgery, Peking University, China-Japan Friendship School of Clinical Medicine, Beijing, China

› Author Affiliations

Abstract

Diabetic peripheral neuropathic pain (DPNP) is a common manifestation of diabetic peripheral neuropathy (DPN). Although the pathogenesis of DPNP remains unclear, the disinhibition of spinal dorsal horn neuronal circuitry mediated by endoplasmic reticulum stress (ERS) is an important mechanism underlying neuropathic pain (NP). Tanshinone II A is mainly used to treat cardiovascular diseases but has also been shown to relieve various types of neuralgia, including DPNP. This study investigated the effects of tanshinone II A in DPNP model rats. We divided animals into two groups: 1) the model (diabetic) group and 2) the tanshinone II A-treatment group. Our results demonstrated that diabetic rats exhibited a decrease in the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL), and that NMT is increased and TWL is prolonged in rats treated with tanshinone II A. Additionally, the levels of ERS-signaling pathway factors in the spinal dorsal horns of rats were lower in the tanshinone II A-treated group than in the diabetic group. Overall, our study demonstrated that the disinhibition of spinal dorsal horn neuronal circuitry mediated by endoplasmic reticulum stress underlies DPNP and is modulated by tanshinone II A treatment.

Key words

diabetic peripheral neuropathic pain - endoplasmic reticulum stress - inhibitory interneuron - Tanshinone II A

Full Text

References

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