GIP ist ein Inkretinhormon, das durch westliche Ernährung verstärkt freigesetzt wird und so zu einer ungesunden metabolischen Wirkung beiträgt – Werner-Creutzfeldt-Preis 2019 – eine Kurzübersicht des Preisträgers Andreas F. H. Pfeiffer

Ungesunde Ernährung ist eine der Hauptursachen der Zivilisationskrankheiten wie Typ-2-Diabetes (T2DM), Atherosklerose und Demenz. Das Darmhormon glukoseinduziertes insulinotropes Peptid (GIP) wird im oberen Dünndarm durch schnell verdauliche, typischerweise hochverarbeitete, energiedichte Nahrungsmittel freigesetzt und stimuliert die frühe Insulinsekretion und eine effektive Energie-Speicherung und damit die Entstehung der Adipositas, aber auch Insulinresistenz und gestörte Glukosetoleranz. Nahrung, die weniger GIP freisetzt, ist deshalb gesünder.

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