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Pharmacopsychiatry 2020; 53(03): 122-132
DOI: 10.1055/a-1096-1266
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Blonanserin patch vs. Other Antipsychotics for Acute Schizophrenia: A Systematic Review of Double-blind, Randomized, Placebo-controlled, Phase 3 Trials in Japan

Taro Kishi
1   Department of Psychiatry, Fujita Health University, Toyoake, Japan
,
Reiji Yoshimura
2   Department of Psychiatry University of Occupational and Environmental Health Japan, Psychiatry, Kitakyushu, Japan
,
Yuki Matsuda
1   Department of Psychiatry, Fujita Health University, Toyoake, Japan
,
Kenji Sakuma
1   Department of Psychiatry, Fujita Health University, Toyoake, Japan
,
Nakao Iwata
1   Department of Psychiatry, Fujita Health University, Toyoake, Japan
› Author Affiliations Role of the Funding Source: This work was supported by the Health and Labor Sciences Research Grant and Grant-in-Aid for Scientific Research (C)(19K08082) and by the Health and Labor Sciences Research Grants (H29-seishin-ippan-001).
Further Information

Publication History

received 31 October 2019
revised 17 December 2019

accepted 21 December 2019

Publication Date:
30 January 2020 (online)

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Abstract

Introduction The use of the blonanserin patch (BLO-P) for schizophrenia treatment was approved in Japan in 2019. This systematic review of trials in Japan assessed the efficacy and safety profile of BLO-P compared with other antipsychotics.

Methods The systematic review included 6-week, double-blind, randomized, placebo-controlled, phase 3 trials in Japan that included patients with acute schizophrenia. Pooled data for patients receiving BLO-P 40 and 80 mg/day (BLO-P40+80) were compared with pooled data for patients receiving asenapine 10 and 20 mg/day (ASE10+20) and data for those receiving brexpiprazole 2 mg/day (BRE2) and paliperidone extended-release 6 mg/day (PAL-ER6).

Results All the investigated treatments were superior to placebo in reducing the Positive and Negative Syndrome Scale (PANSS) total score; the Hedges’ g values (95% confidence interval) for BLO-P40+80, ASE10+20, BRE2, and PAL-ER6 were−0.40 (−0.58,−0.22),−0.61 (−0.79,−0.42),−0.33 (−0.60,−0.07), and−0.69 (−0.93,−0.45), respectively. There were differences among the antipsychotics in the incidence of various individual adverse events.

Discussion BLO-P40+80 may have a good efficacy/safety/tolerability profile for the treatment of patients with acute schizophrenia.

Keywords

asenapine - blonanserin patch - brexpiprzole - paliperidone extended-release - acute schizophrenia

Supplementary Material

 

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