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Klin Padiatr 2020; 232(05): 275-278
DOI: 10.1055/a-1210-2639
Short Communication

COVID-19 in a Child with Pre-Existing Immunodeficiency, Cardiomyopathy, and Chronic Pulmonary Disease

COVID-19 bei einem Kind mit vorbestehendem Immundefekt, Kardiomyopathie und chronischer Lungenerkrankung
Lars Dinkelbach
1   Department of Pediatric Oncology, Hematology and Clinical Immunology, Centre for Child and Adolescent Health, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf
2   Centre for Child and Adolescent Health, HELIOS Klinikum, Krefeld, Krefeld
,
Julia Franzel
3   Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf
,
Martin Andree Berghäuser
4   Department of Pediatrics, Florence-Nightingale-Hospital, Düsseldorf, Düsseldorf
,
Thomas Hoehn
3   Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf
,
Sujal Ghosh
1   Department of Pediatric Oncology, Hematology and Clinical Immunology, Centre for Child and Adolescent Health, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf
,
Unaa Lee
3   Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf
,
Dominik Wulf
3   Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf
,
Jörg Schaper
5   Department of Diagnostic and Interventional Radiology, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf
,
Björn Jensen
6   Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf
,
Tim Niehues
2   Centre for Child and Adolescent Health, HELIOS Klinikum, Krefeld, Krefeld
,
Felix Distelmaier
3   Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf
,
Jennifer Neubert
1   Department of Pediatric Oncology, Hematology and Clinical Immunology, Centre for Child and Adolescent Health, University Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Düsseldorf
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Background

Comorbidities like cardiovascular and respiratory diseases, diabetes or active cancer were identified as major risk factors for SARS-CoV-2 related morbidity and mortality in adults (Onder G et al., JAMA 2020). In children, no risk factors for COVID-19 have been defined so far.

We describe the clinical course of COVID-19 in a 7-year-old boy with autosomal recessively inherited folliculin interacting protein 1 (FNIP1) deficiency whose phenotype is characterized by conditions associated with a more severe outcome of COVID-19.



Publication History

Article published online:
06 August 2020

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