TumorDiagnostik & Therapie 2020; 41(08): 521-526
DOI: 10.1055/a-1211-0859
Schwerpunkt Kopf-Hals-Tumoren

Moderne Therapiekonzepte bei Kopf-Hals-Tumoren

Henrike Barbara Zech
,
Chia-Jung Busch

Die aktuellen Standards in der Therapie von Kopf-Hals-Karzinomen unterliegen einem deutlichen Wandel. Dieser Beitrag hebt beispielhaft Änderungen in der systemischen Therapie in den letzten Jahren hervor und diskutiert mögliche zukünftige Neuerungen auf der Grundlage aktueller wissenschaftlicher Studien.



Publication History

Article published online:
07 October 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • Literatur

  • 1 Siegel RL, Miller KD, Jemal A. Cancer Statistics 2017. CA Cancer J Clin 2017; 67: 7-30
  • 2 Vermorken JB, Mesia R, Rivera F. et al Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 2008; 359: 1116-1127
  • 3 Ferris RL, Blumenschein Jr G, Fayette J. et al Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck. N Engl J Med 2016; 375: 1856-1867
  • 4 Cohen EEW, Soulieres D, Le Tourneau C. et al Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study. Lancet 2019; 393: 156-167
  • 5 Burtness B, Harrington KJ, Greil R. et al Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study. Lancet 2019; 394: 1915-1928
  • 6 Fuchs H, Pammer J, Minichsdorfer C. et al Modified biweekly cisplatin, docetaxel plus cetuximab (TPEx) as first-line treatment for patients with recurrent/metastatic head and neck cancer. Med Oncol 2018; 35: 32
  • 7 Guigay J, Fayette J, Mesia R. et al TPExtreme randomized trial: Quality of Life (QoL) and survival according to second-line treatments in patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). ASCO Virtual Scientific Program 2020: 6520
  • 8 Li W, Wildsmith S, Ye J. et al Plasma-based tumor mutational burden (bTMB) as predictor for survival in phase III EAGLE study: Durvalumab (D) ± tremelimumab (T) versus chemotherapy (CT) in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) after platinum failure. ASCO Virtual Scientific Program 2020: 6511
  • 9 Starzer AM, Heller G, Tomasich E. et al DNA methylation profiling in patients with head and neck squamous cell carcinoma treated with immune checkpoint inhibitors. ASCO Virtual Scientific Program 2020: e18527
  • 10 Gavrielatou N, Doumas S, Economopoulou P. et al Biomarkers for immunotherapy response in head and neck cancer. Cancer Treat Rev 2020; 84: 101977
  • 11 Haider SP, Burtness B, Yarbrough WG. et al Applications of radiomics in precision diagnosis, prognostication and treatment planning of head and neck squamous cell carcinomas. Cancers of the Head & Neck 2020; 5: 6
  • 12 Vellanki PJ, Marur S, Bandaru P. et al Evaluation of the correlation between antibiotic use and survival in patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) treated with immune checkpoint inhibitors (ICIs). ASCO Virtual Scientific Program 2020: 6509
  • 13 Cohen EEW, Nabell L, Wong DJ. et al Phase 1b/2, open label, multicenter study of intratumoral SD-101 in combination with pembrolizumab in anti-PD-1 treatment naïve patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). ASCO Annual Meeting 2019: 6039
  • 14 Felip E, Doger B, Majem M. et al Initial results from a phase II study (TACTI-002) in metastatic non-small cell lung or head and neck carcinoma patients receiving eftilagimod alpha (soluble LAG-3 protein) and pembrolizumab. ASCO Virtual Scientific Program 2020: 3100
  • 15 Angevin E, Groenland SL, Lim AML. et al Updated analysis of the inducible T-cell co-stimulatory receptor (ICOS) agonist, GSK3359609 (GSK609), combination with pembrolizumab (PE) in patients (pts) with anti-PD-1/L1 treatment-naïve head and neck squamous cell carcinoma (HNSCC). ASCO Virtual Scientific Program 2020: 6517
  • 16 Chung CH, Bonomi MR, Steuer CE. et al Concurrent cetuximab (CTX) and nivolumab (NIVO) in patients with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): Results of phase II study. ASCO Virtual Scientific Program 2020: 6515
  • 17 Cohen RB, Bauman JR, Salas S. et al Combination of monalizumab and cetuximab in recurrent or metastatic head and neck cancer patients previously treated with platinum-based chemotherapy and PD-(L)1 inhibitors. ASCO Virtual Scientific Program 2020: 6516
  • 18 Taylor MH, Lee CH, Makker V. et al Phase IB/II Trial of Lenvatinib Plus Pembrolizumab in Patients With Advanced Renal Cell Carcinoma, Endometrial Cancer, and Other Selected Advanced Solid Tumors. J Clin Oncol 2020; 38: 1154-1163
  • 19 Zehir A, Benayed R, Shah RH. et al Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nat Med 2017; 23: 703-713
  • 20 Drilon A, Laetsch TW, Kummar S. et al Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children. N Engl J Med 2018; 378: 731-739
  • 21 Li BT, Shen R, Offin M. et al Ado-trastuzumab emtansine in patients with HER2/amplified salivary gland cancers (SGCs): Results from a phase II basket trial. ASCO Annual Meeting 2019; 6001
  • 22 Tchekmedyian V, Sherman EJ, Dunn L. et al Phase II Study of Lenvatinib in Patients With Progressive, Recurrent or Metastatic Adenoid Cystic Carcinoma. J Clin Oncol 2019; 37: 1529-1537
  • 23 Keam B, Kang EJ, Ahn MJ. et al Randomized phase II study of axitinib versus observation in patients with recurred or metastatic adenoid cystic carcinoma. ASCO Virtual Scientific Program 2020: 6503
  • 24 Ho AL, Hanna GJ, Scholz CR. et al Preliminary activity of tipifarnib in tumors of the head and neck, salivary gland and urothelial tract with HRAS mutations. ASCO Virtual Scientific Program 2020: 6504
  • 25 Cancer Genome Atlas N. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature 2015; 517: 576-582
  • 26 Kiyota N, Tahara M, Fujii H. et al Phase II/III trial of post-operative chemoradiotherapy comparing 3-weekly cisplatin with weekly cisplatin in high-risk patients with squamous cell carcinoma of head and neck (JCOG1008). ASCO Virtual Scientific Program: 2020: 6502
  • 27 Ferris RL, Flamand Y, Weinstein GS. et al Transoral robotic surgical resection followed by randomization to low- or standard-dose IMRT in resectable p16+ locally advanced oropharynx cancer: A trial of the ECOG-ACRIN Cancer Research Group (E3311). ASCO Virtual Scientific Program 2020: 6500
  • 28 Mehanna H, Rischin D, Wong SJ. et al De-Escalation After DE-ESCALATE and RTOG 1016: A Head and Neck Cancer InterGroup Framework for Future De-Escalation Studies. J Clin Oncol 2020; 38: 2552-2557
  • 29 Noronha V. The three pillars of systemic therapy. Vortrag und Diskussion. Im Internet: meetinglibrary.asco.org/record/178133/video ASCO Annual Meeting 2019. Stand: 29.07.2020
  • 30 Kao HF, Lou PJ. Immune checkpoint inhibitors for head and neck squamous cell carcinoma: Current landscape and future directions. Head Neck 2019; 41 (Suppl. 01) 4-18