Abstract
Pain models are mostly in rodents and between them formalin orofacial test
allow discrimination among antinociception and anti-inflammation. This assay
use a formalin solution injected into the upper right lip of each mouse
which produces two periods of pain separated by an inactive period. The aims
of the present study were to evaluate, by means of the isobolographic
analysis, the antinociception and anti-inflammatory activities of the
following NSAIDs: dexketoprofen, diclofenac, piroxicam and metamizole in an
orofacial. The NSAIDs administered intraperitoneally produced a
dose-dependent activity with the following order of potency of the rubbing
behavior, in phase I:
diclofenac>dexketoprofen>piroxicam>metamizole and in
the phase II:
metamizole>diclofenac>piroxicam>dexketoprofen. The
coadministration of NSAIDs resulted in a synergistic interaction, which
according to the value of the potency of the combination (II) presents the
following range: dexketoprofen plus metamizole>dexketoprofen plus
diclofenac>dexketoprofen plus piroxicam, in phase I and
dexketoprofen plus metamizole>dexketoprofen plus
piroxicam>dexketoprofen plus diclofenac, on the phase II. Data
obtained in this work corroborate that NSAIDs alone or in combination
inducing activities by additional mechanism of action supplementary to
inhibition of COXs. This fact represent a novel approach that could be used
as multimodal management of orofacial pain, since with this treatment
strategies, by the reduction of doses, can help to diminish side effects of
other dugs such opioids.
Key words
NSAIDs - synergism - nociception - inflammation - formalin test
