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Nuklearmedizin 2020; 59(06): 443-444
DOI: 10.1055/a-1233-8523
Case Report

False-positive findings in inflammatory processes using 99mTc-PSMA

Knut Liepe
  Nuclear Medicine, Klinikum Frankfurt Oder GmbH, Frankfurt (Oder), Germany
,
Marcel Baehr
  Nuclear Medicine, Klinikum Frankfurt Oder GmbH, Frankfurt (Oder), Germany
,
Bernd Kuhn
  Nuclear Medicine, Klinikum Frankfurt Oder GmbH, Frankfurt (Oder), Germany
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Introduction

Concerning extraskeletal metastases, 68Ga-prostate-specific membrane antigen (PSMA) PET/CT is the diagnostic modality of first choice. However, the costs for the 68Ge/68Ga generator are high and PET/CT systems are not available worldwide. The use of 99 mTc-labelled PSMA SPECT/CT could be helpful to improve the medical health service provision of patients with PSA relapse. Recent studies show similar distribution patterns of 99 mTc-PSMA and 68Ga -PSMA with somewhat lower sensitivity as 68Ga-PSMA PET/CT, especially in small lesions [1]. Besides expression of PSMA in malignancies other than prostate cancer, false positive findings were described in benign lesions such as ganglia of the sympathetic trunk, benign bone lesions or lymph nodes with follicular hyperplasia [2] as well as in inflammatory disorders, including infectious lung diseases, sarcoidosis and granulomatosis with polyangiitis [3]. This case report describes false positive findings in subcutaneous abscess and chronic osteitis at Os pubis.



Publication History

Article published online:
01 September 2020

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  • References

  • 1 Lawal IO, Ankrah AO, Mokgoro NP. et al. Diagnostic sensitivity of Tc-99m HYNIC PSMA SPECT/CT in prostate carcinoma: A comparative analysis with Ga-68 PSMA PET/CT. Prostate 2017; 77: 1205-1212
    CrossrefPubMedGoogle Scholar
  • 2 Sheikhbahaei S, Werner RA, Solnes LB. et al. Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer: An Update on Important Pitfalls. Semin Nucl Med 2019; 49: 255-270
    CrossrefPubMedGoogle Scholar
  • 3 Pyka T, Weirich G, Einspieler I. et al. 68Ga-PSMA-HBED-CC PET for Differential Diagnosis of Suggestive Lung Lesions in Patients with Prostate Cancer. J Nucl Med 2016; 57: 367-371
    CrossrefPubMedGoogle Scholar
  • 4 Ceci F, Uprimny C, Nilica B. et al (68)Ga-PSMA PET/CT for restaging recurrent prostate cancer: which factors are associated with PET/CT detection rate?. Eur J Nucl Med Mol Imaging 2015; 42: 1284-1294 . doi:10.1007/s00259-015-3078-6
    CrossrefPubMedGoogle Scholar
  • 5 Hoberück S, Michler E, Kaiser D. et al. Prostate-Specific Membrane Antigen Expression in Distal Radius Fracture. Clin Nucl Med 2018; 43: 611-613
    CrossrefPubMedGoogle Scholar