Die Therapie offener infizierter Wunden

Infizierte Wunden stellen im Praxisalltag oft eine besondere Herausforderung dar. Trotz zahlreicher Therapiemöglichkeiten ist eine offene Wundbehandlung bei manchen Patienten unumgänglich. Der vorliegende Artikel gibt einen Überblick über aktuell gängige Behandlungsmethoden bei offenen infizierten Wunden.

• Literatur

• 1 Witte MB, Barbul A. General principles of wound healing. Surg Clin North Am 1997; 77 (03) 509-528
• 2 Martin P. Wound healing – aiming for perfect skin regeneration. Science 1997; 276(5309): 75-81
• 3 Boateng JS, Matthews KH, Stevens HN. et al. Wound healing dressings and drug delivery systems: a review. J Pharm Sci 2008; 97 (08) 2892-2923
• 4 Russell L. Understanding physiology of wound healing and how dressings help. Br J Nurs 2000; 9 (01) 10-21
• 5 Bohling MW, Henderson RA, Swaim SF. et al. Cutaneous wound healing in the cat: a macroscopic description and comparison with cutaneous wound healing in the dog. Vet Surg 2004; 33 (06) 579-587
• 6 Bohling MW, Henderson RA, Swaim SF. et al. Comparison of the role of the subcutaneous tissues in cutaneous wound healing in the dog and cat. Vet Surg 2006; 35 (01) 3-14
• 7 Swift ME, Kleinman KH, DiPietro LA. Impaired wound repair and delayed angiogenesis in aged mice. Lab Invest 1999; 79 (12) 1479-1487
• 8 Anderson K, Hamm RL. Factors that impair wound healing. J Am Coll Clin Wound Spec 2014; 4 (04) 84-91
• 9 Michael FYN. Cachexia – an intrinsic factor in wound healing. Intern Wound J 2010; 7 (02) 107-113
• 10 Volk SW, Bohling MW. Comparative wound healing – are the small animal veterinarianʼs clinical patients an improved translational model for human wound healing research?. Wound Repair Regen 2013; 21 (03) 372-381
• 11 Balsa IM, Culp WT. Wound care. Vet Clin North Am Small Anim Pract 2015; 45 (05) 1049-1065
• 12 Hunt TK, Hopf HW. Wound healing and wound infection. What surgeons and anesthesiologists can do. Surg Clin North Am 1997; 77 (03) 587-606
• 13 Schierle CF, De la Garza M, Mustoe TA. et al. Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model. Wound Repair Regen 2009; 17 (03) 354-359
• 14 Johnson-Neitman JL, Bahr RJ, Broaddus KD. Fistula formation secondary to a nylon cable band in a dog. Vet Radiol Ultrasound 2006; 47 (04) 355-357
• 15 Bolton LL, Monte K, Pirone LA. Moisture and healing: beyond the jargon. Ostomy Wound Manage 2000; 46 (1A Suppl): 51S-62S quiz 63S–64S
• 16 Guo S, DiPietro LA. Factors affecting wound healing. J Dent Res 2010; 89 (03) 219-229
• 17 Nolff MC. Modernes Wundmanagement bei Hund und Katze. Stuttgart: Thieme; 2020
• 18 Hess CT. The art of skin and wound care documentation. Advanc Skin Wound Care 2005; 18 (01) 43-53
• 19 Baharestani M, Goltrup F, Holstein P, Vanscheidt W. eds. The clinical relevance of debridement. Berlin, Heidelberg: Springer; 1999
• 20 Davidson JR. Current concepts in wound management and wound healing products. Vet Clin North Am Small Anim Pract 2015; 45 (03) 537-564
• 21 Ousey K, Rippon M. HydroClean^® plus: a new perspective to wound cleansing and debridement. Wounds 2016; 12 (01) 94
• 22 Herberger K, Franzke N, BLome Ch. et al. Efficacy, tolerability and patient benefit of ultrasound-assisted wound treatment versus surgical debridement: a randomized clinical study. Dermatol 2011; 222 (03) 244-249
• 23 Ramundo J, Gray M. Enzymatic wound debridement. J Wound Ostomy Continence Nurs 2008; 35 (03) 273-280
• 24 Gottrup F, Jørgensen B. Maggot debridement: an alternative method for debridement. Eplasty 2011; 11: e33
• 25 Sherman RA, Stevens H, Ng D. et al. Treating wounds in small animals with maggot debridement therapy: a survey of practitioners. Vet J 2007; 173 (01) 138-143
• 26 Bergstrom N, Bennett M, Carlson C. Treatment of pressure ulcers: clinical practice guideline (No. 15). Public Health Service, Agency for Health Care Policy and Research 1994; (95 – 0652).
• 27 Dale BA, Wright DH. Say goodbye to wet-to-dry wound care dressings: changing the culture of wound care management within your agency. Home Healthc Nurse 2011; 29 (07) 429-440
• 28 Hassinger SM, Harding G, Wongworawat MD. High-pressure pulsatile lavage propagates bacteria into soft tissue. Clin Orthop Relat Res 2005; 439: 27-31
• 29 Muñoz-Mahamud E, Garcia S, Bori G. et al. Comparison of a low-pressure and a high-pressure pulsatile lavage during débridement for orthopaedic implant infection. Arch Orthop Trauma Surg 2011; 131 (09) 1233-1238
• 30 Riyat MS, Quinton DN. Tap water as a wound cleansing agent in accident and emergency. J Accid Emerg Med 1997; 14 (03) 165-166
• 31 Willy C, Scheuermann-Poley C, Stichling M. et al. [Importance of wound irrigation solutions and fluids with antiseptic effects in therapy and prophylaxis: Update 2017]. Unfallchirurg 2017; 120 (07) 549-560
• 32 Roberts SM, Severin GA, Lavach JD. Antibacterial activity of dilute povidone-iodine solutions used for ocular surface disinfection in dogs. Am J Vet Res 1986; 47 (06) 1207-1210
• 33 Kampf G. Acquired resistance to chlorhexidine – is it time to establish an ‘antiseptic stewardship’ initiative?. J Hosp Infect 2016; 94 (03) 213-227
• 34 Elkins JG, Hassett DJ, Stewart PS. et al. Protective role of catalase in Pseudomonas aeruginosa biofilm resistance to hydrogen peroxide. Appl Environ Microbiol 1999; 65 (10) 4594-4600
• 35 Percival SL, Bowler PG, Russell D. Bacterial resistance to silver in wound care. J Hosp Infect 2005; 60 (01) 1-7
• 36 Duran N, Temiz M, Duran GG. et al. Relationship between the resistance genes to quaternary ammonium compounds and antibiotic resistance in staphylococci isolated from surgical site infections. Med Sci Monit 2014; 20: 544-550
• 37 Koburger T, Hübner NO, Braun M. et al. Standardized comparison of antiseptic efficacy of triclosan, PVP-iodine, octenidine dihydrochloride, polyhexanide and chlorhexidine digluconate. J Antimicrob Chemother 2010; 65 (08) 1712-1719
• 38 Nolff MC, Winter S, Reese S. et al. Comparison of polyhexanide, cold atmospheric plasma and saline in the treatment of canine bite wounds. J Small Anim Pract 2019; 60 (06) 348-355
• 39 Kaiser S, Kramer M, Thiel C. [Severe complications after non-intended usage of octenidine dihydrochloride. A case series with four dogs]. Tierarztl Prax Ausg K Kleintiere Heimtiere 2015; 43 (05) 291-298
• 40 Flynn J. Povidone-iodine as a topical antiseptic for treating and preventing wound infection: a literature review. Br J Community Nurs 2003; 8 (Suppl. 02) 36-42
• 41 Hirsch T, Koerber A, Jacobsen F. et al. Evaluation of toxic side effects of clinically used skin antiseptics in vitro. J Surg Res 2010; 164 (02) 344-350
• 42 Kramer A, Dissemond J, Kim S. et al. Consensus on wound antisepsis: update 2018. Skin Pharmacol Physiol 2018; 31 (01) 28-58
• 43 Fernández LG, Matthews MR, Seal L. Intraabdominal lavage of hypochlorous acid: a new paradigm for the septic and open abdomen. Wounds 2020; 32 (04) 107-114
• 44 Swaim SF, Renberg WC, Shike KM. Small Animal Bandaging, Casting, and Splinting Techniques. Ames, Iowa: John Wiley & Sons; 2011
• 45 Rajendran S, Anand SC. Insight into the development of non-adherent, absorbent dressings. J Wound Care 2002; 11 (05) 191-195
• 46 Campbell BG. Dressings, bandages, and splints for wound management in dogs and cats. Vet Clin North Small Anim Pract 2006; 36 (04) 759-791
• 47 Rueda López J, Perejamo MA, Bueno AMM. et al. [Combined polyurethane foam and hydrogel dressing. Outcome in lesions of diverse etiology]. Rev Enferm 2004; 27 (11) 51-56
• 48 Fossum TW. Chirurgie der Kleintiere. 5. Aufl.. München: Urban & Fischer/Elsevier; 2020
• 49 Lee WR, Tobias KM, Bemis DA. et al. In vitro efficacy of a polyhexamethylene biguanide-impregnated gauze dressing against bacteria found in veterinary patients. Vet Surg 2004; 33 (04) 404-411
• 50 Kerihuel JC. Effect of activated charcoal dressings on healing outcomes of chronic wounds. J Wound Care 2010; 19 (05) 208-215
• 51 Percival SL, Thomas J, Linton S. et al. The antimicrobial efficacy of silver on antibiotic-resistant bacteria isolated from burn wounds. Int Wound J 2012; 9 (05) 488-493
• 52 Krahwinkel D, Boothe HW. Topical and systemic medications for wounds. Vet Clin North Am Anim Pract 2006; 36 (04) 739-757
• 53 Cooper R. Honey for wound care in the 21^st century. J Wound Care 2016; 25 (09) 544-552
• 54 Molan P, Rhodes T. Honey: a biologic wound dressing. Wounds 2015; 27 (06) 141-151
• 55 Chirife J, Scarmato G, Herszage L. Scientific basis for use of granulated sugar in treatment of infected wounds. Lancet 1982; 319(8271): 560-561
• 56 Kamat N. Use of sugar in infected wounds. Trop Doct 1993; 23 (04) 185
• 57 Mathews KA, Binnington AG. Wound management using sugar. Comp Contin Educ Pract Vet 2002; 24: 41-50
• 58 Nolff MC, Albert R, Reese S. et al. Comparison of negative pressure wound therapy and silver-coated foam dressings in open wound treatment in dogs: a prospective controlled clinical trial. Vet Comp Orthop Traumatol 2018; 31 (04) 229-238
• 59 Nolff MC, Meyer-Lindenberg A. [Negative pressure wound therapy (NPWT) in small animal medicine. Mechanisms of action, applications and indications]. Tierarztl Prax Ausg K Kleintiere Heimtiere 2016; 44 (01) 26-37 quiz 38
• 60 Demaria M, Stanley BJ, Hauptmann JG. et al. Effects of negative pressure wound therapy on healing of open wounds in dogs. Vet Surg 2011; 40 (06) 658-669
• 61 Nolff MC, Pieper K, Meyer-Lindenberg A. Treatment of a perforating thoracic bite wound in a dog with negative pressure wound therapy. J Am Vet Med Assoc 2016; 249 (07) 794-800
• 62 Nolff MC, Layer A, Meyer-Lindenberg A. Negative pressure wound therapy with instillation for body wall reconstruction using an artificial mesh in a Dachshund. Aust Vet J 2015; 93 (10) 367-372
• 63 Swaim SF. Bandages and topical agents. Vet Clin North Am Small Anim Pract 1990; 20 (01) 47-65
• 64 Anderson DM, White RA. Ischemic bandage injuries: a case series and review of the literature. Vet Surg 2000; 29 (06) 488-498
• 65 Swaim SF, Lee A, Henderson R. Mobility versus immobility in the healing of open wounds. J Am Anim Hosp Assoc. 1989
• 66 Broussard KC, Powers JG. Wound dressings: selecting the most appropriate type. Am J Clin Dermatol 2013; 14 (06) 449-459
• 67 Xavier G. Asepsis. Nurs Stand 1999; 13 (36) 49-53 quiz 55
• 68 Briggs M, Torra i Bou JE. European Wound Management Association. Understanding the origin of wound pain during dressing change. Ostomy Wound Manage 2003; 49 (02) 10-12
• 69 Desai C, Wood FM, Schug SA. et al. Effectiveness of a topical local anaesthetic spray as analgesia for dressing changes: a double-blinded randomised pilot trial comparing an emulsion with an aqueous lidocaine formulation. Burns 2014; 40 (01) 106-112