Adipositas als Risikofaktor für Parodontitis

Adipositas gilt als Risikofaktor für die Entstehung der Parodontitis. Dabei sind die zugrunde liegenden Mechanismen sehr vielfältig. Eine effektive Therapie berücksichtigt die verschiedenen Einflussfaktoren und setzt sowohl lokal am Infektions- und Entzündungsgeschehen in der Mundhöhle, aber auch systemisch am Ernährungs- und Lebensstil an. Um Patienten bei der Gewichtsreduktion unterstützen zu können, liefert dieser Fortbildungsbeitrag Informationen zur Charakterisierung und Behandlung von Übergewicht im Kontext der Parodontitis.

Publication History

Article published online:
15 March 2021

• Literatur

• 1 Perlstein M, Bissada N. Influence of obesity and hypertension on the severity of periodontitis in rats. Oral Surg Oral Med Oral Pathol 1977; 43: 707-719
• 2 Al-Zahrani MS, Bissada NF, Borawski EA. Obesity and periodontal disease in young, middle-aged, and older adults. J Periodontol 2003; 74: 610-615
• 3 Vanhala M, Vanhala P, Kumpusalo E. et al. Relation between obesity from childhood to adulthoodand the metabolic syndrome: Population based study. BMJ 1998; 317: 319
• 4 Wood N, Johnson RB, Streckfus CF. Comparison of body composition and periodontal disease using nutritional assessment techniques: Third National Health and Nutrition Examination Survey (NHANES III). J Clin Periodontol 2003; 30: 321-327
• 5 Rexrode K, Carey V, Hennekens C. et al. Abdominal obesity and coronary heart disease in woman. JAMA 1998; 280: 1843-1848
• 6 Suvan J, Harrington Z, Petrie A. et al. Obesity as predictive factor of periodontal therapy clinical outcomes. A cohort study. J Clin Periodontol 2020; 47: 594-601
• 7 Pischon N, Heng N, Bernimoulin JP. et al. Obesity, inflammation, and periodontal disease. J Dent Res 2007; 86: 400-409
• 8 Genco RJ, Grossi SG. Ho Anet al. A proposed model linking inflammation to obesity, diabetes, and periodontal infections. J Periodontol 2005; 76: 2075-2084
• 9 Kim EJ, Jin BH, Bae KH. Periodontitis and obesity: a study of the Fourth Korean National Health an Nutrition Examination Survey. J Periodontol 2011; 82: 533-542
• 10 Gallagher D, Heymsfield SB, Heo M. et al. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr 2000; 72: 694-701
• 11 Flegal KM. Excess deaths associated with underweight, overweight, and obesity. JAMA 2005; 293: 1861-1867
• 12 Ahima RS, Osei SY. Adipokines in obesity. Front Horm Res 2008; 36: 182-197
• 13 Eivazi M, Falahi N, Eivazi N. et al. The effect of scaling and root planning on salivary TNF-α and IL-1α concentrations in patients with chronic periodontitis. Open Dent J 2017; 11: 573-580
• 14 Alipourfad I, Datukishvili N, Mikeladze D. TNF-α downregulation modifies insulin receptor substrate-1 (IRS-1) in metabolic signaling of diabetic insulin-resistant hepatocytes. Mediators Inflamm 2019; 2019: 3560819
• 15 Azuma Y, Kaji K, Katogi R. et al. Tumor necrosis factor-α induces differentiation of and bone resorption by osteoclasts. J Biol Chem 2000; 275: 4858-4864
• 16 Nigro E, Scudiero O, Monaco ML. et al. New insight into adiponectin role in obesity and obesity-related disease. Biomed Res Int 2014; 2014: 658913
• 17 Esfahani M, Movahedian A, Baranchi M. et al. Adiponectin: an adipokine with protective features against metabolic syndrome. Iran J Basic Med Sci 2015; 18: 430-442
• 18 Higdon JV, Frei B. Obesity and oxidative stress – a direct link to CVD?. Arterioscler Thromb Vasc Biol 2003; 23: 365-367
• 19 Bournat JC, Brown CW. Mitochondrial dysfunction in obesity. Curr Opin Endocrinol Diabetes Obes 2010; 17: 446-452
• 20 Furukawa S, Fujita T, Shimabukuru M. et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004; 114: 1752-1761
• 21 Sorochynska OM, Bayliak MM, Gospodaryov DV. et al. Every-other-day feeding decreases glycolytic and mitochondrial energy-producing potentials in the brain and liver of young mice. Front Physiol 2019; 10: 1432
• 22 La Fleur SE, Luijendijk MC, van der Zwaal EM. et al. The snacking rat as model of human obesity: effects of a free-choice high-fat high-sugar diet on meal patterns. Int J Obes 2014; 38: 643-649
• 23 Saito T, Shimazaki Y, Koga T. et al. Relationship between upper body obesity and periodontitis. J Dent Res 2001; 80: 1631-1636
• 24 Bianchi VE. Weight loss is a critical factor to reduce inflammation. Clin Nutr ESPEN 2018; 28: 21-35
• 25 Vivekananda L, Faizuddin M. Effect of weight reduction on the serum adiponectin and tumor necrosis factor-α levels and the clinical parameters of obese patients with and without periodontal disease. J Int Soc Prev Community Dent 2019; 9: 166-171
• 26 Dodington DW, Fritz PC, Sullivan PJ. et al. Higher intakes of fruits and vegetables, β-carotene, vitamin C, α-tocopherol, EPA and DHA are positively associated with periodontal healing after nonsurgical periodontal therapy in nonsmokers but not in smokers. J Nutr 2015; 145: 2512-2519
• 27 Carr AC, Maggini S. Vitamin C and immune function. Nutrients 2017; 9: 1211
• 28 Staudte H, Kranz S, Völpel A. et al. Comparison of nutrient intake between patients with periodontitis and healthy subjects. Quintessence Int 2012; 43: 907-916
• 29 Merchant AT. Plasma vitamin C is inversely associated with periodontitis. J Evid Based Dent Pract 2008; 8: 103
• 30 Chung OK, Chung SJ, Claykombe KJ. et al. Serum C-reactive protein concentrations are inversely associated with dietary with dietary flavonoid intake in U.S. adults. J Nutr 2008; 138: 753-760
• 31 Dickinson S, Hancock DP, Petocz P. et al. High-glykemic index carbohydrate increases nuclear factor-kB activation in mononuclear cells of young lean healthy subjects. Am J Clin Nutr 2008; 87: 1188-1193
• 32 Qi L, Hu FB. Dietary glycemic load, whole grains, and systemic inflammation in diabetes: the epidemiological evidence. Curr Opin Lipidol 2007; 18: 3-8
• 33 King DE, Egan BM, Woolson RF. et al. Effect of a high-fiber diet vs. a fiber-supplemented diet on C-reactive protein level. Arch Intern Med 2007; 167: 502-506
• 34 Freire MO, Van Dyke TE. Natural resolution of inflammation. Periodontol 2000 2013; 63: 149-164
• 35 Naqvi AZ, Buettner C, Phillips RS. et al. N-3 fatty acids and periodontitis in US adults. J Am Diet Assoc 2010; 110: 1669-1675
• 36 Ferreira RO, Correa MG, Magno MB. et al. Physical activity reduces the prevalence of periodontal disease: systematic review and meta-analysis. Front Physiol 2019; 10: 234