Download PDF
kleintier konkret 2021; 24(03): 38-47
DOI: 10.1055/a-1407-1150
Innere Medizin

Exokrine Pankreasinsuffizienz beim Hund und bei der Katze

Florian Wall
,
Kimberly Bartels
,
Susanne Mangelsdorf-Ziera
› Further Information
Also available at
    Permissions and Reprints All articles of this category

Die exokrine Pankreasinsuffizienz von Hund und Katze kann sowohl diagnostisch als auch therapeutisch zur Herausforderung werden. Der vorliegende Beitrag gibt einen aktuellen Überblick.

Literaturverzeichnis als PDF



Publication History

Article published online:
22 June 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • Literatur

  • 1 Ettinger SJ, Feldmann EC. Textbook of Veterinary Internal Medicine: Diseases of the Dog and the Cat. St. Louis: Elsevier; 2017
    Google Scholar
  • 2 Lindkvist B. Diagnosis and treatment of pancreatic exocrine insufficiency. World J Gastroenterol 2013; 19 (42) 7258-7266
    CrossrefPubMedGoogle Scholar
  • 3 Xenoulis PG, Zoran DL, Fosgate GT. et al. Feline exocrine pancreatic insufficiency: a retrospective study of 150 cases. J Vet Intern Med 2016; 30 (06) 1790-1797
    CrossrefPubMedGoogle Scholar
  • 4 Westermarck E, Wiberg M. Exocrine pancreatic insufficiency in the dog: historical background, diagnosis and treatment. Top Companion Anim Med 2012; 27 (03) 96-103
    CrossrefPubMedGoogle Scholar
  • 5 Westermarck E, Saari SAM, Wiberg ME. Heritability of exocrine pancreatic insufficiency in German Shepherd dogs. J Vet Intern Med 2010; 24: 450-452
    CrossrefPubMedGoogle Scholar
  • 6 Westermarck E, Wiberg M. Exocrine pancreatic insufficiency in dogs. Vet Clin North Am Small Anim Pract 2003; 33 (05) 1165-1179
    CrossrefPubMedGoogle Scholar
  • 7 German AJ. Exocrine pancreatic insufficiency in the dog: breed associations, nutritional considerations, and long-term outcome. Top Companion Anim Med 2012; 27 (03) 104-108
    CrossrefPubMedGoogle Scholar
  • 8 Alvarez MS, Herreia-Bustillo V, Font-Utset A. et al. Juvenile diabetes mellitus and concurrent exocrine pancreatic insufficiency in a Labrador Retriever: long-term management. J Am Anim Hosp Assoc 2015; 51 (06) 419-423
    CrossrefPubMedGoogle Scholar
  • 9 Brenner K, Harkin KR, Andrews GA. et al. Juvenile pancreatic atrophy in Greyhounds: 12 cases (1995–2000). J Vet Intern Med 2009; 23 (01) 67-71
    CrossrefPubMedGoogle Scholar
  • 10 Wiberg ME, Saari SA, Westermarck E. Exocrine pancreatic atrophy in German shepherd dogs and rough-coated collies: an end result of lymphocytic pancreatitis. Vet Pathol 1999; 36 (06) 530-541
    CrossrefPubMedGoogle Scholar
  • 11 Westermarck E. The hereditary nature of canine pancreatic degenerative atrophy in the German shepherd dog. Acta Vet Scand 1980; 21 (03) 389-394
    CrossrefPubMedGoogle Scholar
  • 12 Moeller EM, Steiner JM, Clark LA. et al. Inheritance of pancreatic acinar atrophy in German shepherd dogs. Am J Vet Res 2002; 63 (10) 1429-1434
    CrossrefPubMedGoogle Scholar
  • 13 Tsai KL, Noorai RE, Starr-Moss AN. et al. Genome-wide association studies for multiple diseases of the German shepherd dog. Mamm Genome 2012; 23 (1 – 2): 203-211
    CrossrefPubMedGoogle Scholar
  • 14 Batchelor DJ, Noble PJM, Cripps PJ. et al. Breed associations for canine exocrine pancreatic insufficiency. J Vet Intern Med 2007; 21 (02) 207-214
    CrossrefPubMedGoogle Scholar
  • 15 Westermarck E, Batt RM, Vaillant C. et al. Sequential study of pancreatic structure and function during development of pancreatic acinar atrophy in dogs and the role of external factors in the development of the disease. Am J Vet Res 1993; 54: 1088-1094
    PubMedGoogle Scholar
  • 16 Proschowsky HF, Fredholm M. Exocrine pancreatic insufficiency in the Eurasian dog breed: inheritance and exclusion of two candidate genes. Anim Genet 2007; 38 (02) 171-173
    CrossrefPubMedGoogle Scholar
  • 17 Clark LA, Cox ML. Current status of genetic studies of exocrine pancreatic insufficiency in dogs. Top Companion Anim Med 2012; 27 (03) 109-112
    CrossrefPubMedGoogle Scholar
  • 18 Wiberg ME, Saari SAM, Westermarck E. et al. Cellular and humoral immune responses in atrophic lymphocytic pancreatitis in German shepherd dogs and rough-coated collies. Vet Immunol Immunopathol 2000; 76 (1 – 2): 103-115
    CrossrefPubMedGoogle Scholar
  • 19 Wiberg ME, Westermarck E. Subclinical exocrine pancreatic insufficiency in dogs. J Am Vet Med Assoc 2002; 220 (08) 1183-1187
    CrossrefPubMedGoogle Scholar
  • 20 Xenoulis PG, Suchodolski JS, Steiner JM. Chronic pancreatitis in dogs and cats. Compend Contin Educ Vet 2008; 30 (03) 166-180
    PubMedGoogle Scholar
  • 21 Watson PJ. Exocrine pancreatic insufficiency as an end stage of pancreatitis in four dogs. J Small Anim Pract 2003; 44 (07) 306-312
    CrossrefPubMedGoogle Scholar
  • 22 Watson PJ. Chronic pancreatitis in dogs. Top Companion Anim Med 2012; 27 (03) 133-139
    CrossrefPubMedGoogle Scholar
  • 23 Thompson KA, Parnell NK, Hohenhaus AE. et al. Feline exocrine pancreatic insufficiency: 16 cases (1992–2007). J Feline Med Surg 2009; 11 (12) 935-940
    CrossrefPubMedGoogle Scholar
  • 24 Kook PH, Zerbe P, Reusch CE. Exokrine Pankreasinsuffizienz bei der Katze. Schweiz Arch Tierheilkd 2011; 153: 19-25
    CrossrefPubMedGoogle Scholar
  • 25 Steiner JM. Exocrine pancreatic insufficiency in the cat. Top Companion Anim Med 2012; 27 (03) 113-116
    CrossrefPubMedGoogle Scholar
  • 26 Simpson KW, Batt RM, Jones D. et al. Effects of exocrine pancreatic insufficiency and replacement therapy on bacterial flora in the duodenum of dogs. Am J Vet Res 1990; 51 (02) 203-206
    PubMedGoogle Scholar
  • 27 Bright JM. Pancreatic adenocarcinoma in a dog with maldigestion syndrome. J Am Vet Med Assoc 1985; 187 (04) 420-421
    PubMedGoogle Scholar
  • 28 Xenoulis PG, Fradkin JM, Rapp SW. et al. Suspected isolated pancreatic lipase deficiency in a dog. J Vet Intern Med 2007; 21 (05) 1113-1116
    CrossrefPubMedGoogle Scholar
  • 29 Viviano KR, Ziglioli V. Suspected isolated pancreatic enzyme deficiencies in dogs. J Vet Intern Med 2013; 27 (03) 558-591
    CrossrefPubMedGoogle Scholar
  • 30 Carriere F, Laugier R, Barrowman JA. et al. Gastric and pancreatic lipase levels during a test meal in dogs. Scand J Gastroenterol 1993; 28 (05) 443-454
    CrossrefPubMedGoogle Scholar
  • 31 DiMagno EP, Go VL, Summerskill WH. Relations between pancreatic enzyme output and malabsorption in severe pancreatic insufficiency. N Eng J Med 1973; 288 (16) 813-815
    CrossrefPubMedGoogle Scholar
  • 32 Honneffer JB, Minamoto Y, Suchodolski JS. Microbiota alterations in acute and chronic gastrointestinal inflammation in cats and dogs. World J Gastroenterol 2014; 20 (44) 16489-16497
    CrossrefPubMedGoogle Scholar
  • 33 Westermarck E, Myllys V, Aho M. Effect of treatment on the jejunal and colonic bacterial flora of dogs with exocrine pancreatic insufficiency. Pankreas 1993; 8 (05) 559-562
    Google Scholar
  • 34 Williams DA, Batt RM, McLean L. Bacterial overgrowth in the duodenum of dogs with exocrine pancreatic insufficiency. J Am Vet Med Assoc 1987; 191 (02) 201-206
    PubMedGoogle Scholar
  • 35 Blake AB, Guard BC, Honneffer JB. et al. Altered microbiota, fecal lactate and fecal bile acids in dogs with gastrointestinal disease. PloS One 2019; 14 (10) e0224454
    CrossrefPubMedGoogle Scholar
  • 36 Isaiah A, Parambeth JC, Steiner JM. et al. The fecal microbiome of dogs with exocrine pancreatic insufficiency. Anaerobe 2017; 45: 50-58
    CrossrefPubMedGoogle Scholar
  • 37 Soetart N, Rochel D, Drut A. Serum cobalamin and folate as prognostic factors in canine exocrine pancreatic insufficiency: An observational cohort study of 299 dogs. Vet J 2019; 243: 15-20
    CrossrefPubMedGoogle Scholar
  • 38 Simpson KW, Morton DB, Batt RM. Effect of exocrine pancreatic insufficiency on cobalamin absorption in dogs. Am J Vet Res 1989; 50 (08) 1233-1236
    PubMedGoogle Scholar
  • 39 Batchelor DJ, Noble PJM, Taylor RH. et al. Prognostic factors in canine exocrine pancreatic insufficiency: prolonged survival is likely if clinical remission is achieved. J Vet Intern Med 2007; 21 (01) 54-60
    CrossrefPubMedGoogle Scholar
  • 40 Barko PC, Williams DA. Serum concentrations of lipid-soluble vitamins in dogs with exocrine pancreatic insufficiency treated with pancreatic enzymes. J Vet Intern Med 2018; 32 (05) 1600-1608
    CrossrefPubMedGoogle Scholar
  • 41 Perry LA, Williams DA, Pidgeon GL. et al. Exocrine pancreatic insufficiency with associated coagulopathy in a cat. J Am Hosp Assoc 1991; 27: 109-114
    Google Scholar
  • 42 Adamama-Moraitou KK, Rallis TS, Papazoglou LG. et al. Liver biochemical and histopathological findings in dogs with experimentally induced exocrine pancreatic insufficiency. Can J Vet Res 2004; 68 (01) 56-61
    PubMedGoogle Scholar
  • 43 Grützner N, Cranford SM, Norby B. et al. Evaluation of serum cobalamin concentrations in dogs of 164 dog breeds (2006–2010). J Vet Diagn Invest 2012; 24 (06) 1105-1114
    CrossrefPubMedGoogle Scholar
  • 44 Spillmann T, Wittker A, Teigelkamp S. et al. An immunoassay for canine pancreatic elastase 1 as an indicator for exocrine pancreatic insufficiency in dogs. J Vet Diagn Invest 2001; 13 (06) 468-474
    CrossrefPubMedGoogle Scholar
  • 45 Spillmann T, Wilberg ME, Teigelkamp S. et al. Canine faecal pancreatic elastase (cE1) in dogs with clinical exocrine pancreatic insufficiency, normal dogs and dogs with chronic enteropathies. Eur J Comp Gastroent 2000; 5: 1-6
    Google Scholar
  • 46 Battersby IA, Peters IR, Day MJ. et al. Effect of intestinal inflammation on fecal elastase concentration in dogs. J Vet Clin Pathol 2005; 34 (01) 49-51
    CrossrefPubMedGoogle Scholar
  • 47 Steiner JM, Rehfeld JF, Pantchev N. Evaluation of fecal elastase and serum cholecystokinin in dogs with a false positive fecal elastase test. J Vet Intern Med 2010; 24 (03) 643-646
    CrossrefPubMedGoogle Scholar
  • 48 Steiner JM, Williams DA. Serum feline trypsin-like immunoreactivity in cats with exocrine pancreatic insufficiency. J Vet Intern Med 2000; 14 (06) 627-629
    CrossrefPubMedGoogle Scholar
  • 49 Williams DA, Batt RM. Sensitivity and specificity of radioimmunoassay of serum trypsin-like immunoreactivity for the diagnosis of canine exocrine pancreatic insufficiency. J Am Vet Med Assoc 1988; 192 (02) 195-201
    PubMedGoogle Scholar
  • 50 Waritani T, Okuno Y, Ashida Y. et al. Development of a canine trypsin-like immunoreactivity assay system using monoclonal antibodies. Vet Immunol Immunopathol 2002; 87 (1 – 2): 41-49
    CrossrefPubMedGoogle Scholar
  • 51 Steiner JM, Finco DR, Williams DA. Serum feline trypsin-like immunoreactivity (fTLi) in cats with experimentally induced chronic renal failure. J Vet Intern Med 2002; 16: 385 (abstract)
    Google Scholar
  • 52 Wiberg ME, Lautala HM, Westermarck E. Response to long-term enzyme replacement treatment in dogs with exocrine pancreatic insufficiency. J Am Vet Med Assoc 1998; 213 (01) 86-90
    PubMedGoogle Scholar
  • 53 Parambeth JC, Fosgate GT, Suchodolski JS. et al. Randomized placebo controlled clinical trial of an enteric coated micro-pelleted formulation of a pancreatic enzyme supplement in dogs with exocrine pancreatic insufficiency. J Vet Intern Med 2018; 32 (05) 1591-1599
    CrossrefPubMedGoogle Scholar
  • 54 Snead E. Oral ulceration and bleeding associated with pancreatic enzyme supplementation in a German shepherd with pancreatic acinar atrophy. Can Vet J 2006; 47 (06) 579-582
    PubMedGoogle Scholar
  • 55 Rutz GM, Steiner JM, Williams DA. Oral bleeding associated with pancreatic enzyme supplementation in three dogs with exocrine pancreatic insufficiency. J Am Vet Med Assoc 2002; 221 (12) 1716-1718 1714
    CrossrefPubMedGoogle Scholar
  • 56 Pidgeon G. Effect of diet on exocrine pancreatic insufficiency in dogs. J Am Vet Med Assoc 1982; 181 (03) 232-235
    PubMedGoogle Scholar
  • 57 Suzuki A, Mizumoto A, Rerknimitr R. et al. Effect of bacterial or porcine lipase with low- or high-fat diets on nutrient absorption in pancreatic insufficient dogs. Gastroenterology 1999; 116 (02) 431-437
    CrossrefPubMedGoogle Scholar
  • 58 Biourge V, Fontaine J. Exocrine pancreatic insufficiency and adverse reaction to food in dogs: a positive response to a high-fat, soy isolate hydrolysate-based diet. J Nutr 2004; 134: 2166S-2168S
    CrossrefPubMedGoogle Scholar
  • 59 Westermarck E, Wiberg ME. Effects of diet on clinical signs of exocrine pancreatic insufficiency in dogs. J Am Vet Med Assoc 2006; 228 (02) 225-229
    CrossrefPubMedGoogle Scholar
  • 60 Berghoff N, Suchodolski JS, Steiner JM. Association between serum cobalamin and methylmalonic acid concentrations in dogs. Vet J 2012; 191 (03) 306-311
    CrossrefPubMedGoogle Scholar
  • 61 Toresson L, Steiner JM, Suchodolski JS. et al. Oral cobalamin supplementation in dogs with chronic enteropathies and hypocobalaminemia. J Vet Intern Med 2016; 30 (01) 101-107
    CrossrefPubMedGoogle Scholar
  • 62 Toresson L, Steiner JM, Spodsberg E. et al. Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations. Vet J 2019; 243: 8-14
    CrossrefPubMedGoogle Scholar
  • 63 Toresson L, Steiner JM, Spodsberg E. et al. Effects of oral cobalamin supplementation on serum cobalamin concentrations in dogs with exocrine pancreatic insufficiency: A pilot study. Vet J 2021; 269: 105619
    CrossrefPubMedGoogle Scholar
  • 64 Texas A & M University. Veterinary Medicine & Biomedcial Sciences: Cobalamin information. Im Internet (Stand: März 2021): https://vetmed.tamu.edu/gilab/research/cobalamin-information/
    Google Scholar
  • 65 Parkinson S, Tolbert K, Messenger K. et al. Evaluation of the effect of orally administered acid suppressants on intragastric pH in cats. J Vet Intern Med 2015; 29 (01) 104-112
    CrossrefPubMedGoogle Scholar
  • 66 Pilla R, Gaschen FP, Barr JW. et al. Effect of metronidazole on the fecal microbiome and metabolome in healthy dogs. J Vet Intern Med 2020; 34 (05) 1853-1866
    CrossrefPubMedGoogle Scholar
  • 67 Barko PC, McMichael MA, Swanson KS. et al. The gastrointestinal microbiome (Review). J Vet Intern Med 2018; 32: 9-25
    CrossrefPubMedGoogle Scholar
  • 68 Ziese AL, Suchodolski JS, Hartmann K. et al. Effect of probiotic treatment on the clinical course, intestinal microbiome and toxigenic Clostridium perfringens in dogs with acute hemorrhagic diarrhea. PloS One 2018; 13 (09) e0204691
    CrossrefPubMedGoogle Scholar
  • 69 Rossi G, Pengo G, Caldin M. et al. Comparison of microbiological, histological and immunomodulatory parameters in response to treatment with either combination therapy with prednisone and metronidazole or probiotic VSL#3 strains in dogs with idiopathic inflammatory bowel disease. PLoS One 2014; 9 (04) e94699
    CrossrefPubMedGoogle Scholar
  • 70 Roth N. Exokrine Pankreasinsuffizienz bei Hunden: Toleranz- und Wirkungsstudie mit Pankreatin (Albrecht), retrospektive Untersuchungen zur Prognose und Überlebenszeit [Dissertation]. Gießen: Justus-Liebig-Universität; 2010
    PubMedGoogle Scholar