Ernährung & Medizin 2021; 36(02): 68-76
DOI: 10.1055/a-1483-2924
Wissen

Vitamin-D-Versorgung und die Gesundheit von schwangeren Frauen und Kindern bis zum Schulalter

Anja Werken
,
Rima Obeid

Zusammenfassung

Die derzeitige Studienlage weist Unklarheiten in Bezug auf Folgen einer Vitamin-D-Unterversorgung für Mutter und Kind sowie Plasma-Referenzwerte für Vitamin D und Aufnahmeempfehlungen auf. Die vorliegende Studie untersucht auf Basis einer systematischen Suche und Metaanalyse die Evidenzlage zum Zusammenhang von mütterlichem und kindlichem Vitamin D mit bestimmten gesundheitlichen Endpunkten.



Publication History

Article published online:
08 June 2021

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  • Literatur

  • 1 Dietary reference values for vitamin D. EFSA Journal 2016; 14: e04547
  • 2 Principi N, Bianchini S, Baggi E. et al. Implications of maternal vitamin D deficiency for the fetus, the neonate and the young infant. Eur J Nutr 2013; 52: 859-867
  • 3 Deutsche Gesellschaft für Ernährung. Ausgewählte Fragen und Antworten zu Vitamin D. Im Internet: https://www.dge.de/wissenschaft/weitere-publikationen/faqs/vitamin-d/?L=0 (Stand: 22.10.2012)
  • 4 Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357: 266-281
  • 5 Vitamin D Referenzwerte D-A-CH. Im Internet: https://www.dge.de/wissenschaft/referenzwerte/vitamin-d/?L=0 (Stand: 13.03.2021)
  • 6 Liu NQ, Hewison M. Vitamin D, the placenta and pregnancy. Arch Biochem Biophys 2012; 523: 37-47
  • 7 Hollis BW, Johnson D, Hulsey TC. et al. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 2011; 26: 2341-2357
  • 8 Akbari S, Khodadadi B, Ahmadi SAY. et al. Association of vitamin D level and vitamin D deficiency with risk of preeclampsia: A systematic review and updated meta-analysis. Taiwanese J Obstet Gynecol 2018; 57: 241-247
  • 9 Palacios C, Kostiuk LK, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2019
  • 10 Hu Z, Tang L, Xu H-L. Maternal vitamin D deficiency and the risk of small for gestational age: A Meta-analysis. Iran J Public Health 2018; 47: 11
  • 11 Bi WG, Nuyt AM, Weiler H. et al. Association between vitamin D supplementation during pregnancy and offspring growth, morbidity, and mortality: A systematic review and meta-analysis. JAMA Pediatrics 2018; 172: 635
  • 12 Tous M, Villalobos M, Iglesias L. et al. Vitamin D status during pregnancy and offspring outcomes: a systematic review and meta-analysis of observational studies. Eur J Clin Nutr 2019; 74: 36-53
  • 13 Maugeri A, Barchitta M, Blanco I. et al. Effects of vitamin D supplementation during pregnancy on birth size: A systematic review and meta-analysis of randomized controlled trials. Nutrients 2019; 11: 442
  • 14 Wei Z, Zhang J, Yu X. Maternal vitamin D status and childhood asthma, wheeze, and eczema: A systematic review and meta-analysis. Pediatr Allergy Immunol 2016; 27: 612-619
  • 15 Pacheco-González RM, García-Marcos L, Morales E. Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta-analysis of observational studies. Pediatr Allergy Immunol 2018; 29: 243-253
  • 16 Amraei M, Mohamadpour S, Sayehmiri K. et al. Effects of vitamin D deficiency on incidence risk of gestational diabetes mellitus: A systematic review and meta-analysis. Front Endocrinol 2018; 9: 7
  • 17 Pérez-López FR, Pasupuleti V, Mezones-Holguin E. et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril 2015; 103: 1278-1288.e4
  • 18 Wang J, Liu N, Sun W. et al. Association between vitamin D deficiency and antepartum and postpartum depression: a systematic review and meta-analysis of longitudinal studies. Arch Gynecol Obstet 2018; 298: 1045-1059
  • 19 Shi D, Wang D, Meng Y. et al. Maternal vitamin D intake during pregnancy and risk of asthma and wheeze in children: a systematic review and meta-analysis of observational studies. J Maternal-Fetal Neonat Med 2019; 34: 653-659
  • 20 Aghajafari F, Nagulesapillai T, Ronksley PE. et al. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. BMJ 2013; 346: f1169
  • 21 Hu L, Zhang Y, Wang X. et al. Maternal vitamin D status and risk of gestational diabetes: a meta-analysis. Cell Physiol Biochem 2018; 45: 291-300
  • 22 Lu M, Xu Y, Lv L. et al. Association between vitamin D status and the risk of gestational diabetes mellitus: a meta-analysis. Arch Gynecol Obstet 2016; 293: 959-966
  • 23 Zhang M-X, Pan G-T, Guo J-F. et al. Vitamin D deficiency increases the risk of gestational diabetes mellitus: A meta-analysis of observational studies. Nutrients 2015; 7: 8366-8375
  • 24 Poel YHM, Hummel P, Lips P. et al. Vitamin D and gestational diabetes: A systematic review and meta-analysis. Eur J Intern Med 2012; 23: 465-469
  • 25 Ojo O, Weldon SM, Thompson T. et al. The effect of vitamin D supplementation on glycaemic control in women with gestational diabetes mellitus: A systematic review and meta-analysis of randomised controlled trials. IJERPH 2019; 16: 1716
  • 26 Jahanjoo F, Farshbaf-Khalili A, Shakouri SK. et al. Maternal and neonatal metabolic outcomes of vitamin D supplementation in gestational diabetes mellitus: A systematic review and meta-analysis. Ann Nutr Metab 2018; 73: 145-159
  • 27 Rodrigues MRK, Molina Lima SA, Ferreira da Silvia Mazeto GM. et al. Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials. PLoS One 2019; 14: e0213006
  • 28 Shen S-Y, Xiao W-Q, Lu J-H. et al. Early life vitamin D status and asthma and wheeze: a systematic review and meta-analysis. BMC Pulm Med 2018; 18: 120
  • 29 Bi WG, Nuyt AM, Weiler H. et al. Association between vitamin D supplementation during pregnancy and offspring growth, morbidity, and mortality: A systematic review and meta-analysis. JAMA Pediatr 2018; 172: 635
  • 30 Haussler MR, Whitfield GK, Kaneko I. et al. Molecular mechanisms of vitamin D action. Calcif Tissue Int 2013; 92: 77-98
  • 31 Berridge MJ. Vitamin D and depression: Cellular and regulatory mechanisms. Pharmacol Rev 2017; 69: 80-92
  • 32 Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol 2005; 289: F8-F28
  • 33 Schedel M, Jia Y, Michel S. et al. 1,25D3 prevents CD8 + Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter. Nat Commun 2016; 7: 10213

  • Weitere Literatur zu den im systematischen Review bzw. in den Metaanalysen eingeschlossenen Studien bei den Verfasserinnen.