Insomnie im Rahmen neurologischer Erkrankungen

Der Artikel liefert einen Überblick über die Prävalenz, Ursache und Behandlung der Insomnie im Rahmen häufiger neurologischer Erkrankungen (Restless-Legs-Syndrom, Schlaganfall, Multiple Sklerose, Morbus Parkinson und Alzheimer-Demenz). Zudem wird auf die wechselseitigen kausalen Zusammenhänge zwischen Schlafstörungen und neurologischen Erkrankungen hingewiesen.

Schlüsselwörter

Insomnie - neurologische Erkrankungen - Behandlung - Diagnostik - Risikofaktor

• Literatur

• 1 Riemann D, Baum E, Cohrs S. et al. S3 Leitlinie Nicht erholsamer Schlaf/Schlafstörungen. AWMF-Registernummer 063-001, Kap „Insomnie bei Erwachsenen“. Somnologie 2017; 20 (Suppl. 02) S97. -S180 Im Internet (Stand: 12.06.2020): https://www.dgsm.de/downloads/aktuelles/S3 LL Nicht-erholsamer Schlaf Kap SBAS 11818_20_s2_2017.pdf
• 2 Allen RP, Picchietti DL, Garcia-Borreguero D. et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria – history, rationale, description, and significance. International Restless Legs Syndrome Study Group. Sleep Med 2014; 15: 860-873
• 3 Winkelmann J, Allen RP, Högl B. et al. Treatment of restless legs syndrome: Evidence-based review and implications for clinical practice. Mov Disord 2018; 33: 1077-1091
• 4 Loke YK, Brown JW, Kwok CS. et al. Association of obstructive sleep apnea with risk of serious cardiovascular events: a systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes 2012; 5: 720-728
• 5 Glozier N, Moullaali TJ, Sivertsen B. et al. The course and impact of poststroke insomnia in stroke survivors aged 18 to 65 years: Results from the Psychosocial Outcomes In StrokE (POISE) Study. Cerebrovasc Dis Extra 2017; 7: 9-20
• 6 Helbig AK, Stöckl D, Heier M. et al. Symptoms of Insomnia and Sleep Duration and Their Association with Incident Strokes: Findings from the Population-Based MONICA/KORA Augsburg Cohort Study. PLoS One 2015; 10: e0134480
• 7 Sahraian MA, Rezaali S, Hosseiny M. et al. Sleep disorder as a triggering factor for relapse in multiple sclerosis. Eur Neurol 2017; 77: 258-261
• 8 Bellesi M, Pfister-Genskow M, Maret S. et al. Effects of sleep and wake on oligodendrocytes and their precursors. J Neurosci 2013; 33: 14288-14300
• 9 Hedström AK, Åkerstedt T, Hillert J. et al. Shift work at young age is associated with increased risk for multiple sclerosis. Ann Neurol 2011; 70: 733-741
• 10 Schrempf W, Brandt MD, Storch A. et al. Sleep disorders in Parkinsonʼs disease. J Parkinsons Dis 2014; 4: 211-221
• 11 Choi JH, Kim HJ, Lee JY. et al. Long-term effects of bilateral subthalamic nucleus stimulation on sleep in patients with Parkinsonʼs disease. PLoS One 2019; 14: e0221219
• 12 Postuma RB, Iranzo A, Hu M. et al. Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. Brain 2019; 142: 744-759
• 13 McKeith IG, Boeve BF, Dickson DW. et al. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology 2017; 89: 88-100
• 14 Lysen TS, Darweesh SKL, Ikram MK. et al. Sleep and risk of parkinsonism and Parkinsonʼs disease: a population-based study. Brain 2019; 142: 2013-2022
• 15 Lim AS, Ellison BA, Wang JL. et al. Sleep is related to neuron numbers in the ventrolateral preoptic/intermediate nucleus in older adults with and without Alzheimerʼs disease. Brain 2014; 137: 2847-2861
• 16 McCleery J, Cohen DA, Sharpley AL. Pharmacotherapies for sleep disturbances in Alzheimerʼs disease. Cochrane Database Syst Rev 2014; (03) CD009178
• 17 La AL, Walsh CM, Neylan TC. et al. Long-term trazodone use and cognition: a potential therapeutic role for slow-wave sleep enhancers. J Alzheimers Dis 2019; 67: 911-921
• 18 Lim AS, Yu L, Kowgier M. et al. Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep. JAMA Neurol 2013; 70: 1544-1551
• 19 Xie L, Kang H, Xu Q. et al. Sleep drives metabolite clearance from the adult brain. Science 2013; 342: 373-377
• 20 Spira AP, Gamaldo AA, An Y. et al. Self-reported sleep and β-amyloid deposition in community-dwelling older adults. JAMA Neurol 2013; 70: 1537-1543